Erythrox 125 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Erythromycin oral |
| Company | Renata limited |
Indications
- Upper respiratory tract infections: Tonsilitis, Peritonsillar abscess, Pharyngitis, Laryngitis, Sinusitis
- Lower respiratory tract infections: Tracheitis, Acute and chronic bronchitis
- Ear infections: Otitis media, Otitis externa, Mastoiditis
- Eye infections: Blepharitis, Established trachoma
- Skin and Soft tissue infections: Boils and carbuncles, Impetigo, Abscesses, Pustular acne, Paromychia, Cellulitis, Erysipelas
- Gastrointestinal tract infections: Cholecystitis, Staphylococcal enterocolitis
- Prophylaxis: Pre and post-operative, Trauma, Burns, Rheumatic fever
- Other infections: Osteomyelitis, Diptheria, Scarlet fever, Whooping cough
Description
Erythrox belongs to the macrolides group of antibiotics and is effective against a wide range of micro-organisms including Gram (+)ve and Gram (-)ve bacteria, mycoplasmas, and chlamydia
Pharmacology
- Mode of action: Inhibits microsomal protein synthesis in susceptible organisms by interfering with the translocation process; specific binding to the 50S subunit or 70S ribosome occurs
- Absorption: Erythromycin base is destroyed by acid and is administered in the form of a stable ester; absorption rates of the base and esters are diminished by food
- Blood concentration: Peak serum concentrations are attained in 1 to 4 hours after an oral dose; serum half-life is 1.2 to 4 hours
- Distribution: Widely distributed throughout body tissue and fluids with some retention in the liver and spleen; enters the cerebrospinal fluid when the meninges are inflamed, crosses the placenta, and is excreted in the milk
- Excretion: 5 to 15% of the dose is excreted in the urine; large amounts of the unchanged active substance are excreted in the bile
Dosage & Administration
- Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections; may be increased up to 4 gm or more daily
- Elderly: No special dosage recommendation; may be administered three times daily or twice daily by giving one-third or half of the total daily requirement 8 hourly or 12 hourly respectively
- Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosages
- Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses
Interaction
Use in patients receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity
Contraindications
Known hypersensitivity to Erythromycin
Side Effects
- Allergic reactions (rare and mild); anaphylaxis has occurred
- Abdominal discomfort after oral administration, sometimes with nausea and vomiting; discomfort usually subsides after a few days
Pregnancy & Lactation
No evidence of teratogenicity or toxicity in humans; caution should be exercised when prescribing to pregnant patients and lactating mothers
Precautions & Warnings
Given with care in patients with impaired hepatic function as it is excreted principally in the bile
Overdose Effects
In case of overdosage, Erythrox should be discontinued; prompt elimination of unabsorbed drug is recommended; not removed by peritoneal dialysis or haemodialysis
Therapeutic Class
Anti-diarrhoeal Antimicrobial drugs, Macrolides
Reconstitution
Shake the bottle to loosen powder; add boiled and cooled water to the dry powder of the bottle and shake well; reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator and unused portion should be discarded after 7 days
Storage Conditions
Keep below 25°C temperature, away from light and moisture; keep out of the reach of children