Eryzen 125 mg/5 ml (Powder for Suspension)

100 ml bottle: ৳ 57.00

Medicine Details

Category	Details
Generic	Erythromycin oral
Company	Zenith pharmaceuticals ltd
Also available as	Eryzen 250 mg tablet Eryzen 500 mg tablet

Indications

Upper respiratory tract infections
Lower respiratory tract infections
Ear infections
Eye infections
Skin and Soft tissue infections
Gastrointestinal tract infections
Prophylaxis
Other infections

Description

Belongs to the macrolides group of antibiotics, bacteriostatic or bactericidal action, used for treatment of infections caused by penicillinase producing staphylococci, susceptible to various micro-organisms.

Pharmacology

Mode of Action: Inhibits microsomal protein synthesis in susceptible organisms by inhibiting the translocation process, specific binding to ribosome occurs, active against many Gram-positive and some Gram-negative bacteria, mycoplasmas, and chlamydia.
Absorption: Destroyed by acid, administered in the form of stable ester, absorption rates diminished by the presence of food.
Blood Concentration: Peak serum concentrations of 0.9 to 1.4 or 0.4 to 1.8 mg/ml after an oral dose of 500 mg, serum half-life is 1.2 to 4 hours.
Distribution: Widely distributed throughout body tissue and fluids with some retention in the liver and spleen, enters the cerebrospinal fluid when the meninges are inflamed.
Excretion: 5 to 15% of the dose excreted in the urine, large amounts of the unchanged active substance excreted in the bile.

Dosage & Administration

Adult and Children over 8 years: 250-500 mg every six hours for mild to moderate infections, may be increased in severe cases,
Elderly: No special dosage recommendation, administered three times daily or twice daily.
Children aged 2 to 8 years: 250 mg every six hours or 30-50 mg/kg body weight per day divided into four equal dosages.
Infants and Children upto 2 years: 500 mg in divided doses or 30-50 mg/kg body weight in divided doses.

Interaction

Use in patients receiving high dosage of theophylline may be associated with an increase of serum theophylline levels and potential theophylline toxicity, dose reduction needed.

Contraindications

Known hypersensitivity to Erythromycin

Side Effects

Allergic reactions
Abdominal discomfort after oral administration
Nausea and vomiting

Pregnancy & Lactation

No evidence of teratogenicity or toxicity in human studies, caution advised when prescribing to pregnant patients and lactating mothers.

Precautions & Warnings

Given with care in patients with impaired hepatic function.

Overdose Effects

Discontinue in case of overdosage, prompt elimination of unabsorbed drug needed, not removed by peritoneal dialysis or haemodialysis.

Therapeutic Class

Anti-diarrheal Antimicrobial drugs
Macrolides

Reconstitution

Direction for reconstitution of suspension provided, reconstituted suspension should be stored in a cool and dry place, preferably in refrigerator, and unused portion should be discarded after 7 days.

Storage Conditions

Keep below 25°C temperature, away from light & moisture, keep out of the reach of children.