Vasopin Plus 5 mg+50 mg (Tablet)

Unit Price: ৳ 4.52 (3 x 10: ৳ 135.60)
Strip Price: ৳ 45.20

Medicine Details

Category Details
Generic Amlodipine besilate atenolol
Company Silva pharmaceuticals ltd

Indications

  • Essential hypertension
  • Angina pectoris & hypertension
  • Post myocardial infarction
  • Refractory angina pectoris

Pharmacology

  • Fixed-dose combination of Amlodipine and Atenolol
  • Amlodipine is a dihydropyridine calcium antagonist
  • Amlodipine acts as a peripheral vasodilator
  • Atenolol is a cardioselective beta-blocker
  • Atenolol reduces blood pressure by lowering cardiac output
  • Atenolol decreases plasma renin activity and sympathetic outflow

Dosage & Administration

  • Recommended dosage: Amlodipine and Atenolol 5/25 mg tablet once daily
  • Dosage may be increased to 5/25 mg two tablets daily
  • Dosage should be individualized

Interaction

  • Disopyramide: Atenolol reduces clearance of disopyramide by 20%
  • Ampicillin: may reduce Atenolol levels at doses of 1 gm and above
  • Oral antidiabetics and insulin: Beta-blockers may decrease tissue sensitivity to insulin and inhibit insulin secretion

Contraindications

  • Hypersensitivity to either component
  • Sinus bradycardia
  • Second and higher degrees of heart block
  • Cardiogenic shock
  • Hypotension
  • Congestive heart failure
  • Poor left ventricular function

Side Effects

  • Fatigue
  • Headache
  • Edema
  • Nausea
  • Drowsiness
  • Anxiety
  • Depression

Pregnancy & Lactation

  • Use during pregnancy only if expected benefit outweighs potential fetal risk
  • Not recommended for nursing mothers

Precautions & Warnings

  • Use with caution in patients with airway obstruction
  • Can be used in patients with renal impairment with caution if creatinine clearance is less than 30 ml/min
  • Caution necessary in severe liver damage due to prolongation of elimination half-life of Amlodipine
  • Patients should be warned against stopping the drug suddenly

Overdose Effects

  • Hypotension
  • Congestive cardiac failure
  • Unabsorbed drugs may be removed by gastric lavage or administration of activated charcoal
  • Symptomatic treatment is suggested

Therapeutic Class

  • Combined antihypertensive preparations

Storage Conditions

  • Keep below 30°C temperature
  • Away from light & moisture
  • Keep out of the reach of children

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