AM 500 mg (Tablet)

Unit Price: ৳ 30.00 (10's pack: ৳ 300.00)

Medicine Details

Category	Details
Generic	Azithromycin dihydrate
Company	Reliance pharmaceuticals ltd
Also available as	Am 200 mg suspension

Azithromycin is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, skin and soft tissue infections, and sexually transmitted diseases. It acts by binding to the 50S ribosomal subunit of susceptible microorganisms.

500 mg once daily orally for 3 days in adults, 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days in sexually transmitted diseases caused by Chlamydia trachomatis in adults. The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is 500 mg as a single daily dose by the intravenous route for at least two days.

Azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. The prolonged terminal half-life is thought to be due to extensive uptake and subsequent release of drug from tissues. Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination.

Azithromycin and antacids should be taken at least 1 hour before or 2 hours after the antacid. Some of the related macrolide antibiotics interfere with the metabolism of cyclosporin. In the absence of conclusive data from pharmacokinetic studies or clinical data, caution should be exercised before co-administration of these two drugs. In patients receiving concomitant azithromycin and digoxin, the possibility of raised digoxin levels should be borne in mind and digoxin levels monitored.

Azithromycin is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic. Co-administration of ergot derivatives and Azithromycin is contraindicated. Azithromycin is contraindicated in patients with hepatic diseases.

Most side-effects observed were gastrointestinal in origin with nauseas, abdominal discomfort, vomiting, flatulence, and diarrhea being occasionally observed. Allergic reactions such as rash or photosensitivity have occurred and there have also been rare reports of serious hypersensitivity reactions. Reversible elevations in liver transaminases have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials.

Pregnancy Category of Azithromycin is B. Animal reproduction studies have demonstrated that Azithromycin has no evidence of harm to the fetus. Caution should be exercised when Azithromycin is administered to nursing women.

As with erythromycin and other macrolides, rare serious allergic reactions, including angioneurotic oedema and anaphylaxis, has been reported. Some of these reactions with azithromycin have resulted in recurrent symptoms and required a long period of observation and treatment.

There is no data on overdosage with AM. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting, and diarrhea. Gastric lavage and general supportive measures are indicated.

Keep in a dry place away from light and heat. Keep out of the reach of children.

AM 500 mg Tablet performs its action by preventing the synthesis of essential proteins required by bacteria to carry out vital functions.
AM 500 mg Tablet is used for the treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections.
Side effects include diarrhea, dry or scaly skin, abdominal pain, vomiting, fever, acid or sour stomach, aggression or anger, and heartburn.
AM 500 mg Tablet should be kept in a cool dry place and its original packaging. Make sure this medication remains unreachable to children and pets.