Apozyth 500 mg (Tablet)
Unit Price: ৳ 30.00 (12's pack: ৳ 360.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Apollo pharmaceutical ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Upper respiratory tract infections
- Sinusitis treatment
- Pharyngitis/tonsillitis treatment
- Otitis media treatment
- Skin and soft tissue infection treatment
- Treatment of non-gonococcal urethritis in men and women
- Treatment of cervicitis due to Chlamydia trachomatis
Pharmacology
- Acid-stable
- Oral administration
- Readily absorbed
- Time to peak concentration
- High concentration in phagocytes
- Active transport to site of infection
- High concentration in tissues
- Ion trapping
- High lipid solubility
- Bacteriostatic levels in infected tissue
- Binding to 50S ribosomal subunit
- Interfering with microbial protein synthesis
- Microbiological activity
- Concentration in plasma and tissues
- Biliary excretion
- Absorption on empty stomach
- Plasma concentrations decline
- Mean apparent plasma clearance
- Terminal elimination half-life
- Polyphasic pattern of decline
- Microbial susceptibility
- Protein synthesis interference
Dosage
- Oral dosage for adults
- Oral dosage for children
- Dosage for sexually transmitted diseases in adults
- Dosage for typhoid fever
- Dosage for ≥16 years in intravenous form
- Dosage for pelvic inflammatory disease
- Safety and effectiveness in children or adolescents
Administration
- Reconstitution procedure for suspension
- Timing of administration in relation to meals
Interaction
- Interaction with antacids
- Pharmacokinetic interaction with carbamazepine
- Interaction with cyclosporin
- Effect on the metabolism of digoxin
- Theoretical risk of ergotism
- Pharmacokinetic interaction with methylprednisolone
- Co-administration with theophylline
- Pharmacodynamic interaction with warfarin
- Effect on terfenadine pharmacokinetics
Contraindications
- Hypersensitivity to Azithromycin or macrolide antibiotics
- Co-administration with ergot derivatives
- Hepatic diseases
Side Effects
- Gastrointestinal side-effects
- Mild to moderate side-effects
- Allergic reactions
- Reversible elevations in liver transaminases
- Rare cases of serious hypersensitivity reactions
- Cholestatic jaundice
- Transient mild reductions in neutrophil counts
- Reversible hearing impairment in prolonged usage
Pregnancy & Lactation
- Pregnancy category
- Animal reproduction studies
- No adequate and well-controlled studies in pregnant women
- Caution in nursing women
Precautions & Warnings
- Rare serious allergic reactions
- Incidence of angioneurotic oedema and anaphylaxis
- Long period of observation and treatment for serious reactions
Use in Special Populations
- No dose adjustment in mild renal impairment
- Caution in more severe renal impairment
- Contradiction in hepatic impairment
- Effect on ability to drive and use machines
Overdose Effects
- Typical symptoms of macrolide antibiotic overdosage
- Hearing loss
- Severe nausea, vomiting and diarrhea
- Indicated measures for overdose treatment
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C38H72N2O12
- Chemical Structure Image
Common Questions about Apozyth 500 mg Tablet
- Action mechanism
- Uses of Apozyth 500 mg Tablet
- List of side effects
- Storage and disposal instructions
- Possibility of diarrhea
- Safety of Apozyth 500 mg Tablet
- Classification as an antibiotic
- Guidance if symptoms don't improve
- Additional quick tips