Apozyth 500 mg (Tablet)

Indications

• Lower respiratory tract infections
• Upper respiratory tract infections
• Sinusitis treatment
• Pharyngitis/tonsillitis treatment
• Otitis media treatment
• Skin and soft tissue infection treatment
• Treatment of non-gonococcal urethritis in men and women
• Treatment of cervicitis due to Chlamydia trachomatis

Pharmacology

• Acid-stable
• Oral administration
• Readily absorbed
• Time to peak concentration
• High concentration in phagocytes
• Active transport to site of infection
• High concentration in tissues
• Ion trapping
• High lipid solubility
• Bacteriostatic levels in infected tissue
• Binding to 50S ribosomal subunit
• Interfering with microbial protein synthesis
• Microbiological activity
• Concentration in plasma and tissues
• Biliary excretion
• Absorption on empty stomach
• Plasma concentrations decline
• Mean apparent plasma clearance
• Terminal elimination half-life
• Polyphasic pattern of decline
• Microbial susceptibility
• Protein synthesis interference

Dosage

• Oral dosage for adults
• Oral dosage for children
• Dosage for sexually transmitted diseases in adults
• Dosage for typhoid fever
• Dosage for ≥16 years in intravenous form
• Dosage for pelvic inflammatory disease
• Safety and effectiveness in children or adolescents

Administration

• Reconstitution procedure for suspension
• Timing of administration in relation to meals

Interaction

• Interaction with antacids
• Pharmacokinetic interaction with carbamazepine
• Interaction with cyclosporin
• Effect on the metabolism of digoxin
• Theoretical risk of ergotism
• Pharmacokinetic interaction with methylprednisolone
• Co-administration with theophylline
• Pharmacodynamic interaction with warfarin
• Effect on terfenadine pharmacokinetics

Contraindications

• Hypersensitivity to Azithromycin or macrolide antibiotics
• Co-administration with ergot derivatives
• Hepatic diseases

Side Effects

• Gastrointestinal side-effects
• Mild to moderate side-effects
• Allergic reactions
• Reversible elevations in liver transaminases
• Rare cases of serious hypersensitivity reactions
• Cholestatic jaundice
• Transient mild reductions in neutrophil counts
• Reversible hearing impairment in prolonged usage

Pregnancy & Lactation

• Pregnancy category
• Animal reproduction studies
• No adequate and well-controlled studies in pregnant women
• Caution in nursing women

Precautions & Warnings

• Rare serious allergic reactions
• Incidence of angioneurotic oedema and anaphylaxis
• Long period of observation and treatment for serious reactions

Use in Special Populations

• No dose adjustment in mild renal impairment
• Caution in more severe renal impairment
• Contradiction in hepatic impairment
• Effect on ability to drive and use machines

Overdose Effects

• Typical symptoms of macrolide antibiotic overdosage
• Hearing loss
• Severe nausea, vomiting and diarrhea
• Indicated measures for overdose treatment

Storage Conditions

• Dry place away from light and heat
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C38H72N2O12
• Chemical Structure Image

Common Questions about Apozyth 500 mg Tablet

• Action mechanism
• Uses of Apozyth 500 mg Tablet
• List of side effects
• Storage and disposal instructions
• Possibility of diarrhea
• Safety of Apozyth 500 mg Tablet
• Classification as an antibiotic
• Guidance if symptoms don't improve
• Additional quick tips

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