Asizith 500 mg (Tablet)

Title

• Asizith 500 mg Tablet

Categories

• Medicine
• Antibiotic

Description

• Asizith is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, skin and soft tissue infections, and sexually transmitted diseases
• Azithromycin is acid-stable and can be taken orally with no need of protection from gastric acids
• Azithromycin has high concentration in phagocytes and active transport to the site of infection
• Asizith is available in oral dosage form and for IV infusion
• Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and interfering with microbial protein synthesis
• Recommended dosage for adults is 500 mg once daily orally for 3 days, and for children, the dosage varies with body weight and condition
• Reconstitution procedure of suspension involves shaking the bottle well and adding boiled and cooled water up to the water mark of the bottle label
• Interaction with antacids, carbamazepine, cyclosporin, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, and terfenadine
• Azithromycin is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic, co-administration of ergot derivatives, and patients with hepatic diseases
• Side effects include gastrointestinal issues, allergic reactions, reversible elevations in liver transaminases, cholestatic jaundice, and hearing impairment
• Pregnancy Category of Azithromycin is B, and caution should be exercised when administered to nursing women
• Rare serious allergic reactions, including angioneurotic oedema and anaphylaxis, have been reported
• Azithromycin should be used with caution in patients with renal impairment, and it should not be used in patients with hepatic disease
• There is no data on overdosage with Asizith, typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting, and diarrhea
• Keep in a dry place away from light and heat, and out of the reach of children

Dimensions

Color Options

Functions

• Prevents the synthesis of essential proteins required by bacteria

Materials

• Azithromycin

Technical Specifications

• Molecular Formula: C38H72N2O12
• Oral and IV dosage forms available

Design Elements

• Chemical structure with molecular formula
• Reconstitution procedure of suspension

Usability Features

• No evidence of effect on a patient’s ability to drive or operate machinery

Indications

• Infections in lower respiratory tract
• Infections in upper respiratory tract
• Otitis media and skin and soft tissue infections
• Sexually transmitted diseases in men and women

Pharmacology

• Azithromycin is readily absorbed
• High concentration in phagocytes
• Actively transported to the site of infection
• Time to peak concentration in adults: 2.1 to 3.2 hours
• Plasma concentrations decline in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min

Dosage

• 500 mg once daily orally for 3 days for adults
• Dosage varies for children based on body weight and condition
• Recommended dosage for IV infusion in adult patients with community-acquired pneumonia

Administration

• Azithromycin should be taken at least 1 hour before or 2 hours after meal

Interaction

• Antacid
• Carbamazepine
• Cyclosporin
• Digoxin
• Ergot derivatives
• Methylprednisolone
• Theophylline
• Warfarin
• Terfenadine

Contraindications

• Hypersensitivity to Azithromycin or any other macrolide antibiotic
• Co-administration of ergot derivatives
• Patients with hepatic diseases

Side Effects

• Gastrointestinal issues
• Allergic reactions
• Elevations in liver transaminases
• Cholestatic jaundice
• Hearing impairment

Pregnancy & Lactation

• Pregnancy Category: B
• Caution should be exercised when administered to nursing women

Precautions & Warnings

• Rare serious allergic reactions reported

Use in Special Populations

• No dose adjustment needed in patients with mild renal impairment
• Caution should be exercised in using azithromycin in patients with severe renal impairment
• Not to be used in patients with hepatic disease

Overdose Effects

• Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C38H72N2O12
• Chemical structure provided with image

Commonly Asked Questions

• Information on uses, side effects, storage, and disposal provided

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