Azimete 200 mg/5 ml (Powder for Suspension)
15 ml bottle: ৳ 85.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Medimet pharmaceuticals ltd |
| Also available as |
Title and Categories
- Azimete 200 mg/5 ml Suspension
- Antibiotic
- Macrolide Antibiotic
Indications
- Lower respiratory tract infections
- Upper respiratory tract infections
- Sinusitis
- Pharyngitis
- Tonsillitis
- Otitis media
- Skin infections
- Soft tissue infections
- Non-gonococcal urethritis
- Cervicitis
Pharmacology
- Orally absorbed
- Greater absorption on empty stomach
- Time to peak concentration: 2.1 to 3.2 hours
- High concentration in phagocytes
- Active transport to site of infection
- Release of high concentrations in active phagocytosis
- High tissue concentration
- Half-life allows large single dose administration
- Bacteriostatic levels maintained for several days
- Plasma clearance: 630 mL/min
- Terminal elimination half-life: 68 hours
- Biliary excretion
- 6% unchanged drug in urine
- Binds to 50S ribosomal subunit
- Interferes with microbial protein synthesis
- Active against various microorganisms
Dosage
- Adult oral dose: 500 mg once daily for 3 days
- Pediatric oral dose: Varies with body weight and indication
- Azithromycin injection for IV infusion in adults
- Dose for community-acquired pneumonia & pelvic inflammatory disease
Administration
- Reconstitution procedure for suspension
- Timing of administration with respect to meals
Interaction
- Interaction with antacids
- Carbamazepine pharmacokinetic interaction
- Cyclosporin metabolism interference
- Digoxin metabolism impairment
- Ergot derivatives co-administration contraindicated
- Methylprednisolone pharmacokinetic interaction
- Theophylline co-administration
- Warfarin pharmacodynamic interaction
- Terfenadine pharmacokinetics
Contraindications
- Hypersensitivity to Azithromycin or macrolide antibiotic
- Co-administration with ergot derivatives
- Hepatic diseases
Side Effects
- Mild to moderate gastrointestinal side-effects
- Allergic reactions
- Hypersensitivity reactions
- Reversible liver transaminase elevations
- Rare cases of serious hypersensitivity reactions
- Cholestatic jaundice
- Mild reductions in neutrophil counts
- Reversible hearing impairment with higher doses
Pregnancy & Lactation
- Pregnancy Category B
- No evidence of harm to the fetus (animal studies)
- Caution during pregnancy
- Unknown secretion in breast milk
- Caution during lactation
Precautions & Warnings
- Rare serious allergic reactions reported
- Caution with angioneurotic oedema and anaphylaxis
Use in Special Populations
- No dose adjustment in mild renal impairment
- Caution in severe renal impairment
- Not to be used in hepatic impairment
- No effect on driving or machinery operation
Overdose Effects
- Typical symptoms of macrolide antibiotic overdosage
- General supportive measures indicated
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children
Chemical Structure
- Molecular Formula: C38H72N2O12
- Chemical Structure Image
Common Questions
- Description of syrup
- Uses of syrup
- Side effects of syrup
- Storage and disposal instructions
- Potential diarrhea as a side effect
- Safety of syrup
- Classification as antibiotic
- Monitoring symptoms and treatment completion instructions