Azin 200 mg/5 ml (Powder for Suspension)
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Acme laboratories ltd |
| Also available as |
Title
Azin 200 mg/5 ml Suspension
Categories
- Medicine
- Antibiotic
- Pharmaceutical
Description
Azin is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, skin and soft tissue, and sexually transmitted diseases. It is acid-stable, readily absorbed, and has high tissue concentration. Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms. It is available in oral and injection forms. Azithromycin should be taken at least 1 hour before or 2 hours after a meal. It is contraindicated in patients hypersensitive to it and those with hepatic diseases. It is well tolerated with a low incidence of side effects.
Dimensions
N/A
Color options
N/A
Functions
- Treatment of bacterial infections
- Prevention of community-acquired pneumonia, pharyngitis/tonsillitis
- Therapy for sexually transmitted diseases
Materials
N/A
Technical specifications
- Oral Adult Dosage:
- 500 mg once daily orally for 3 days
- 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days
- Children Dosage:
- 10 mg/kg body weight once daily for 3 days
- 200 mg for 3 days if body weight is 15-25 kg
- 300 mg for 3 days if body weight is 26-35 kg
- 400 mg for 3 days if body weight is 36-45 kg
- In typhoid fever, 500 mg once daily for 7-10 days
- Injection Dosage:
- 500 mg as a single daily dose by the intravenous route for at least two days
- Single 500 mg daily dose by the oral route to complete a 7 to 10-day course of therapy
Design elements
- Suspension reconstitution procedure
- Chemical structure
Usability features
- No effect on a patient’s ability to drive or operate machinery
Interaction
- Antacid
- Carbamazepine
- Cyclosporin
- Digoxin
- Ergot derivatives
- Methylprednisolone
- Theophylline
- Warfarin
- Terfenadine
Storage conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
Pharmacology
- Absorption: Readily absorbed; greater on an empty stomach
- Peak concentration time in adults: 2.1 to 3.2 hours for oral dosage forms
- Tissue Concentration: Over 50 times higher than in plasma
- Half-life: 68 hours
- Biliary Elimination: Approximately 6% of the administered dose as unchanged drug in urine
- Microbiology: Active against most isolates of various microorganisms
Indications
- Lower respiratory tract infections
- Upper respiratory tract infections
- Otitis media
- Skin and soft tissue infections
- Sexually transmitted diseases
Contraindications
- Hypersensitivity to Azithromycin or any other macrolide antibiotic
- Co-administration of ergot derivatives
- Hepatic diseases
Side effects
- Common:
- Nausea
- Abdominal discomfort
- Vomiting
- Flatulence
- Diarrhea
- Allergic reactions
- Reversible elevations in liver transaminases
- Rare:
- Cholestatic jaundice
- Transient mild reductions in neutrophil counts
- Hearing impairment
Pregnancy lactation
- Pregnancy Category: B
- Usage in Pregnancy: Caution should be exercised when used during pregnancy
- Usage in Lactation: Caution should be exercised when administered to nursing women
Precautions warnings
- Rare serious allergic reactions reported
- Caution in patients with renal impairment
- Not recommended in patients with severe hepatic impairment
Overdose effects
Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting, and diarrhea. Gastric lavage and general supportive measures are indicated.