Azinil 200 mg/5 ml (Powder for Suspension)
20 ml bottle: ৳ 90.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Apex pharmaceuticals ltd |
| Also available as |
Title
Azinil 200 mg/5 ml Suspension
Category
- Medicine
- Antibiotic
- Suspension
Description
Azinil is a medication indicated for various infections in the respiratory tract, skin, and sexually transmitted diseases. Its pharmacology involves binding to microbial ribosomal subunits, interfering with protein synthesis, and having a prolonged half-life. It has specific dosage instructions for both oral and intravenous administration. There are precautions regarding its use in patients with renal or hepatic impairment. Additionally, it has storage and overdose instructions, contraindications, side effects, and considerations for use during pregnancy and lactation.
Indications
- Lower respiratory tract infections
- Upper respiratory tract infections
- Sinusitis
- Pharyngitis/Tonsillitis
- Otitis media
- Skin and soft tissue infections
- Non-gonococcal urethritis
- Cervicitis
Mode of Action
- Oral administration
- Acid stability
- High absorption on empty stomach
- Transport to site of infection via phagocytes
- High tissue concentration
- Bacteriostatic levels for several days
- Large single dose with prolonged effect
- Pharmacokinetics
- Biliary excretion
- Microbial protein synthesis interference
- Nucleic acid synthesis
Dosage
- 500 mg once daily orally for 3 days
- 500 mg once on day 1 followed by 250 mg once on days 2-5
- 1 gm single dose for specific infections in adults
- Doses for children based on body weight
- Azithromycin injection for IV infusion
- Recommended doses for community-acquired pneumonia and pelvic inflammatory disease in adults
- No established safety and effectiveness in children or adolescents
Administration
- Reconstitution procedure for suspension
- Timing in relation to meals
Interaction
- Antacid interaction
- Carbamazepine interaction study
- Cyclosporin interference with metabolism
- Digoxin metabolism impairment
- Ergot derivatives contraindication
- Methylprednisolone study
- Theophylline co-administration
- Warfarin pharmacodynamic interaction
- Terfenadine pharmacokinetics
- Antibiotic-antacid interval
Contraindications
- Hypersensitivity to Azithromycin or macrolide antibiotics
- Co-administration with ergot derivatives
- Hepatic diseases
Side Effects
- Gastrointestinal side effects
- Nausea
- Abdominal discomfort
- Vomiting
- Flatulence
- Diarrhoea
- Allergic reactions
- Reversible elevations in liver transaminases
- Cholestatic jaundice
- Reductions in neutrophil counts
- Hearing impairment
Pregnancy & Lactation
- Pregnancy category B
- No evidence of harm to fetus in animal studies
- Caution advised for use during pregnancy and nursing
Precautions & Warnings
- Rare serious allergic reactions
- Angioneurotic oedema
- Anaphylaxis
- Recurrent symptoms
- Caution in renal impairment
- Caution in hepatic impairment
- No effect on ability to drive or operate machinery
Use in Special Populations
- No dose adjustment for mild renal impairment
- Caution in severe renal impairment
- Effects on ability to drive and use machines
- Hepatic excretion
- No use in hepatic disease
Overdose Effects
- Typical symptoms of macrolide antibiotic overdose
- Hearing loss
- Severe nausea
- Vomiting
- Diarrhoea
- Gastric lavage and supportive measures
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children
Chemical Structure
- Molecular formula: C38H72N2O12
- Chemical structure diagram
Common Questions
- Action of Azinil 200 mg/5 ml Syrup
- Uses of Azinil 200 mg/5 ml Syrup
- Side effects of Azinil 200 mg/5 ml Syrup
- Storage and disposal instructions
- Potential cause of diarrhea
- Safety of Azinil 200 mg/5 ml Syrup
- Classification as an antibiotic
- Need for medical consultation if symptoms persist
- Quick tips for medication adherence