Azithin 500 mg (Tablet)

Unit Price: ৳ 42.00 (3 x 4: ৳ 504.00)
Strip Price: ৳ 168.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Chemist laboratories ltd
Also available as
Azithin 200 mg suspension

Title

  • Azithin 500mg Tablet

Categories

  • Antibiotic
  • Macrolide Antibiotic

Description

  • Azithin is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis, pneumonia, upper respiratory tract infections including sinusitis, pharyngitis/tonsillitis, otitis media, and skin and soft tissue infections. It is also used in sexually transmitted diseases in men and women for non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.

Dosage

  • 500 mg once daily orally for 3 days in adults. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days

Mode of Action

  • Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and interferes with microbial protein synthesis. It is readily absorbed and has a time to peak concentration in adults of 2.1 to 3.2 hours for oral dosage forms.

Interaction

  • Interaction with antacids: Azithromycin should be taken at least 1 hour before or 2 hours after the antacid. Azithromycin does not alter the anticoagulant effect of a single 15 mg dose of warfarin administered to healthy volunteers.

Contraindications

  • Azithromycin is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic, co-administration of ergot derivatives, and in patients with hepatic diseases.

Side Effects

  • Gastrointestinal side-effects such as nausea, abdominal discomfort, vomiting, and diarrhea. Allergic reactions such as rash or photosensitivity have occurred. Reversible elevations in liver transaminases and transient mild reductions in neutrophil counts have been observed. Reversible hearing impairment was seen in some patients with higher doses for prolonged periods.

Pregnancy & Lactation

  • Pregnancy Category B. No evidence of harm to the fetus observed in animal studies. Caution should be exercised when administered to nursing women.

Precautions & Warnings

  • Rare serious allergic reactions have been reported, including angioneurotic edema and anaphylaxis. Recurrent symptoms may occur and require a long period of observation and treatment.

Overdose Effects

  • Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting, and diarrhea. Gastric lavage and general supportive measures are indicated.

Storage Conditions

  • Keep in a dry place away from light and heat. Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C38H72N2O12

Common Questions

  • What is Azithin 500 mg Tablet? It prevents the synthesis of essential proteins required by bacteria.
  • What are the uses of Azithin 500 mg Tablet? It is used for the treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections.
  • What are the Side Effects of Azithin 500 mg Tablet? Side effects include diarrhea, dry or scaly skin, abdominal pain, difficult or painful urination, vomiting, fever, and more.

Use in Renal Impairment

  • No dose adjustment is needed in patients with mild renal impairment (creatinine clearance >40 ml/min), but caution should be exercised in using azithromycin in patients with more severe renal impairment.

Use in Hepatic Impairment

  • It should not be used in patients with hepatic disease as the liver is the principal route of excretion of azithromycin.

Effects on Ability to Drive and Use Machines

  • There is no evidence to suggest that azithromycin may have an effect on a patient's ability to drive or operate machinery.

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