Azithrocin 500 mg (Tablet)

Title and Categories

• Azithrocin 500 mg Tablet
• Pharmaceuticals
• Medicine
• Antibiotics

Indications

• Lower respiratory tract infections treatment
• Upper respiratory tract infections treatment
• Treatment of otitis media
• Treatment of skin and soft tissue infections
• Treatment of sexually transmitted diseases

Mode of Action

• Acid-stable for oral consumption
• Readily absorbed
• Greater absorption on empty stomach
• High concentration in phagocytes
• Active transport to site of infection
• Large concentrations released during phagocytosis
• High concentration in tissues compared to plasma
• Bacteriostatic levels maintained for several days
• Plasma clearance of 630 mL/min
• Terminal elimination half-life of 68 hours
• Biliary excretion as a major route of elimination

Dosage

• 500 mg once daily orally for 3 days (Adult)
• 1 gm as a single dose for sexually transmitted diseases in adults
• Oral dosage for children based on body weight
• 500 mg as a single daily dose for community-acquired pneumonia (IV infusion)

Administration

• Oral administration
• Reconstitution procedure for suspension
• Intake at least 1 hour before or 2 hours after meal

Interaction

• Interaction with antacid
• Pharmacokinetic interaction with carbamazepine
• Pharmacokinetic interaction with cyclosporin
• Impairment of digoxin metabolism
• Incompatibility with ergot derivatives
• Pharmacokinetic interaction with methylprednisolone
• Co-administration with theophylline
• Alteration of warfarin's anticoagulant effect

Contraindications

• Hypersensitivity to Azithromycin or macrolide antibiotics
• Co-administration with ergot derivatives
• Patients with hepatic diseases

Side Effects

• Mild to moderate gastrointestinal side-effects
• Allergic reactions such as rash or photosensitivity
• Reversible elevations in liver transaminases
• Rare cases of serious hypersensitivity reactions
• Transient mild reductions in neutrophil counts
• Reversible hearing impairment in high doses

Pregnancy & Lactation

• Pregnancy Category B
• No evidence of harm to the fetus in animal studies
• Caution in use during pregnancy
• Caution in use by nursing women

Precautions & Warnings

• Rare serious allergic reactions reported
• Caution in use in patients with renal impairment
• Avoid use in patients with hepatic impairment

Use in Special Populations

• No dose adjustment needed in mild renal impairment
• Caution in using Azithromycin in patients with severe renal impairment
• Not to be used in patients with hepatic disease
• No evidence of effect on driving or machinery operation

Overdose Effects

• Typical symptoms of macrolide antibiotic overdosage
• Symptoms include hearing loss, severe nausea, vomiting, and diarrhea
• General supportive measures indicated

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C38H72N2O12

Commonly Asked Questions

• Action of Azithrocin 500 mg Tablet
• Uses of Azithrocin 500 mg Tablet
• Side effects of Azithrocin 500 mg Tablet
• Storage and disposal instructions
• Possibility of diarrhea as a side effect
• Safety of Azithrocin 500 mg Tablet
• Azithrocin 500 mg Tablet classification as antibiotic
• Instructions if no improvement is observed
• Quick Tips for using Azithrocin 500 mg Tablet

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