BP-Z 500 mg (Capsule)

Unit Price: ৳ 30.00 (3's pack: ৳ 90.00)

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Bristol pharmaceuticals ltd
Also available as
Bp z 500 mg tablet Bp z 200 mg suspension

Category

  • Medicine
  • Antibiotic

Title

BP-Z 500 mg Capsule

Dosage

  • 500 mg once daily orally for 3 days or 500 mg once on day 1 then 250 mg once on days 2-5 for 4 days for adults
  • 10 mg/kg body weight once daily for 3 days for children over 6 months
  • Azithromycin Injection for IV Infusion: The recommended dose is 500 mg as a single daily dose by the intravenous route for at least two days

Indications

  • Lower respiratory tract infections
  • Upper respiratory tract infections
  • Otitis media
  • Skin and soft tissue infections
  • Chlamydia trachomatis infections

Pharmacology

  • Absorption: Readily absorbed, greater on empty stomach, time to peak concentration in adults is 2.1 to 3.2 hours
  • Distribution: High concentration in phagocytes, actively transported to site of infection
  • Tissue Concentration: Over 50 times higher than in plasma due to ion trapping and high lipid solubility
  • Elimination: Biliary excretion of azithromycin, approximately 6% appears unchanged in urine

Drug Interaction

  • Antacids: Take at least 1 hour before or 2 hours after
  • Carbamazepine: No significant effect observed on plasma levels
  • Cyclosporin: Exercise caution, monitor cyclosporin levels
  • Digoxin: Monitor digoxin levels
  • Ergot derivatives: Should not be co-administered
  • Methylprednisolone: No significant effect on pharmacokinetics
  • Theophylline: No evidence of pharmacokinetic interaction
  • Warfarin: Did not alter anticoagulant effect
  • Terfenadine: Did not affect pharmacokinetics of terfenadine

Contraindications

  • Hypersensitivity to Azithromycin or macrolide antibiotics
  • Co-administration of ergot derivatives
  • Patients with hepatic diseases

Side Effects

  • Mild to moderate gastrointestinal side-effects
  • Allergic reactions
  • Reversible elevations in liver transaminases
  • Rare cases of cholestatic jaundice
  • Transient mild reductions in neutrophil counts
  • Reversible hearing impairment in some patients

Pregnancy & Lactation

  • Pregnancy Category: B
  • Effect on Fetus: No evidence of harm to the fetus
  • Breastfeeding: Use with caution, not known if secreted in breast milk

Precautions & Warnings

  • Rare serious allergic reactions reported
  • Caution in patients with renal impairment
  • Not recommended in patients with hepatic impairment

Overdose Effects

Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea. Gastric lavage and supportive measures indicated

Storage Conditions

Dry place away from light and heat, keep out of reach of children

Chemical Structure

  • Molecular Formula: C38H72N2O12
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-100-azithromycin-dihydrate-chemical-structure-tFo4BQqfsRzQwcODCGo2.svg

Common Questions

  • What is BP-Z 500 mg Capsule used for?
  • What are the uses of BP-Z 500 mg Capsule?
  • What are the Side Effects of BP-Z 500 mg Capsule?
  • Instructions for storage and disposal of BP-Z 500 mg Capsule
  • Can the use of BP-Z 500 mg Capsule cause diarrhea?
  • Is BP-Z 500 mg Capsule safe?
  • Is BP-Z 500 mg Capsule an antibiotic?
  • What if I don't get better even after taking BP-Z 500 mg Capsule?
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