Curazith 500 mg (Tablet)

Title

• Curazith 500 mg Tablet

Category

• Antibiotic
• Medication
• Pharmaceutical

Indications

• Lower respiratory tract infections
• Upper respiratory tract infections
• Sinusitis
• Pharyngitis
• Tonsillitis
• Otitis media
• Skin infections
• Soft tissue infections
• Non-gonococcal urethritis
• Cervicitis

Pharmacology

• Oral administration
• Acid stability
• Absorption
• Time to peak concentration
• High concentration in phagocytes
• Transport to infection site
• Phagocytosis
• Ion trapping
• High lipid solubility
• Half-life
• Plasma clearance
• Biliary excretion
• Microbial protein synthesis inhibition
• Active against gram-positive microorganisms
• Active against gram-negative microorganisms
• Active against anaerobic microorganisms
• Active against Chlamydia pneumoniae
• Active against Chlamydia trachomatis
• Active against Mycoplasma pneumoniae
• No effect on nucleic acid synthesis

Dosage

• 500 mg once daily for 3 days (adult oral)
• 500 mg once on day 1, then 250 mg once daily for 4 days (adult oral)
• 1 gm single dose or 500 mg once on day 1, then 250 mg daily for 2 days (adult sexually transmitted diseases)
• 10 mg/kg body weight once daily for 3 days (children oral)
• 200 mg for 3 days for 15-25 kg body weight (children oral)
• 300 mg for 3 days for 26-35 kg body weight (children oral)
• 400 mg for 3 days for 36-45 kg body weight (children oral)
• 500 mg once daily for 7-10 days in typhoid fever (children oral)
• 500 mg as a single daily dose by intravenous route for at least two days, followed by oral therapy (adult IV infusion)

Administration

• Reconstitution procedure for suspension
• Shaking the bottle
• Adding boiled and cooled water
• Shaking until powder is completely mixed
• Take at least 1 hour before or 2 hours after meal

Interactions

• Antacid interaction
• Carbamazepine interaction
• Cyclosporin interaction
• Digoxin interaction
• Ergot derivatives interaction
• Methylprednisolone interaction
• Theophylline interaction
• Warfarin interaction
• Terfenadine interaction

Contraindications

• Hypersensitivity to Azithromycin or macrolide antibiotic
• Co-administration with ergot derivatives
• Hepatic diseases

Side Effects

• Gastrointestinal side-effects
• Nausea
• Abdominal discomfort
• Vomiting
• Flatulence
• Diarrhea
• Allergic reactions
• Rash
• Photosensitivity
• Hypersensitivity reactions
• Elevations in liver transaminases
• Cholestatic jaundice
• Reductions in neutrophil counts
• Hearing impairment

Pregnancy & Lactation

• Pregnancy Category B
• Animal reproduction studies
• Caution in pregnant and nursing women

Precautions & Warnings

• Rare serious allergic reactions
• Angioneurotic oedema
• Anaphylaxis
• Monitoring in patients with renal impairment
• Caution in patients with hepatic impairment
• No effect on ability to drive or use machines

Use in Special Populations

• No dose adjustment for mild renal impairment
• Caution in severe renal impairment
• Not to be used in hepatic disease
• No effect on ability to drive or use machines

Overdose Effects

• Typical symptoms of macrolide antibiotic overdosage
• General supportive measures

Storage Conditions

• Dry place
• Away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C38H72N2O12
• Chemical Structure Image

Common Questions

• Curazith 500 mg Tablet action
• Uses of Curazith 500 mg Tablet
• Side Effects of Curazith 500 mg Tablet
• Storage and disposal instructions
• Diarrhea side effect
• Safety of Curazith 500 mg Tablet
• Antibiotic classification
• Monitoring symptoms for improvement

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