Demacro 500 mg (Tablet)
Unit Price: ৳ 30.00 (8's pack: ৳ 240.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Decent pharma laboratories ltd |
| Also available as |
Title
- Demacro 500 mg Tablet
Categories
- Antibiotic
- Macrolide
- Medication
- Pharmaceutical
Indications
- Lower respiratory tract infections
- Upper respiratory tract infections
- Sinusitis
- Pharyngitis
- Tonsillitis
- Otitis media
- Skin and soft tissue infections
- Sexually transmitted diseases
- Non-gonococcal urethritis
- Cervicitis
Pharmacology
- Orally administered
- Acid-stable
- Absorbed readily
- Greater absorption on an empty stomach
- High concentration in phagocytes
- Selective transport to infection site
- Phagocytosis-enhanced release
- High tissue concentration
- Long half-life
- Plasma clearance
- Biliary excretion
- Microorganism protein synthesis inhibition
- Active against gram-positive and gram-negative microorganisms
- No inhibition of nucleic acid synthesis
Dosage
- For adults and children
- 500 mg once daily orally for 3 days
- 500 mg on day 1, then 250 mg on days 2-5
- 1 gm single dose for adults with Chlamydia trachomatis
- 10 mg/kg body weight for children
- Oral and IV administration
- Duration for pelvic inflammatory disease
- Single daily intravenous dose for community-acquired pneumonia
- Biliary excretion as major route
Administration
- Reconstitution procedure for suspension
- Shake well before use
- Add boiled and cooled water as per instructions
- Administer at least 1 hour before or 2 hours after meal
Interaction
- Antacid interaction timing
- Cyclosporin metabolism interference
- Digoxin metabolism impairment
- Ergot derivatives co-administration caution
- Methylprednisolone pharmacokinetics
- Theophylline co-administration monitoring
- Warfarin co-administration monitoring
- Terfenadine pharmacokinetic effects
Contraindications
- Hypersensitivity to Azithromycin or macrolide antibiotics
- Co-administration with ergot derivatives
- Hepatic diseases
Side Effects
- Low incidence of side-effects
- Mild to moderate gastrointestinal side-effects
- Nausea
- Abdominal discomfort
- Vomiting
- Flatulence
- Diarrhoea
- Allergic reactions
- Rash
- Photosensitivity
- Reversible liver transaminase elevations
- Cholestatic jaundice
- Transient neutrofil reductions
- Reversible hearing impairment at higher doses
Pregnancy & Lactation
- Pregnancy Category B
- No evidence of harm to fetus
- Use during pregnancy with caution
- Unknown secretion in breast milk
Precautions & Warnings
- Rare serious allergic reactions reported
- Angioneurotic oedema
- Anaphylaxis
- Long period of observation and treatment
Use in Special Populations
- Renal impairment caution
- No dose adjustment for mild renal impairment
- Hepatic impairment caution
- Effect on ability to drive and use machines
Overdose Effects
- No specific data available
- Typical symptoms of macrolide antibiotic overdosage
- Gastric lavage and general supportive measures
Storage Conditions
- Dry place away from light and heat
- Keep out of reach of children
Chemical Structure
- Molecular Formula : C38H72N2O12
- Chemical Structure Image
Common Questions
- Purpose of Demacro 500 mg Tablet
- Uses of Demacro 500 mg Tablet
- Side effects of Demacro 500 mg Tablet
- Storage and disposal instructions for Demacro 500 mg Tablet
- Diarrhea as a side effect
- Safety of Demacro 500 mg Tablet
- Antibiotic classification
- Failure to improve despite medication
- Quick Tips for Demacro 500 mg Tablet