Hyzith 200 mg/5 ml (Powder for Suspension)
15 ml bottle: ৳ 85.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Millat pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections
- Upper respiratory tract infections
- Sinusitis
- Pharyngitis/Tonsillitis
- Otitis media
- Skin and soft tissue infections
- Sexually transmitted diseases
- Bronchitis
- Pneumonia
- Cervicitis
Pharmacology
- Acid-stable
- Orally administered
- Readily absorbed
- Greater absorption on empty stomach
- High concentration in phagocytes
- Transported to site of infection
- High tissue concentration
- Ion trapping
- High lipid solubility
- Bacteriostatic levels maintained for several days
- Time to peak concentration
- Plasma clearance
- Terminal elimination half-life
- Biliary excretion
- Microbial protein synthesis
- Active against gram-positive and gram-negative microorganisms
Dosage
- 500 mg once daily orally for 3 days
- Alternative dosage for sexually transmitted diseases
- Dosage for children based on body weight
- Azithromycin injection for adult patients with community-acquired pneumonia
- Dose adjustment in pelvic inflammatory disease
- Intravenous therapy followed by oral route
- Safety and effectiveness in children under 16 years not established
Administration
- Reconstitution procedure for suspension
- Shake the bottle well
- Add boiled and cooled water
- Shake until powder is completely mixed
- Timing of intake in relation to meals
Interaction
- Antacid and azithromycin co-administration
- Cyclosporine interference with macrolide antibiotics
- Metabolism interference with digoxin
- Theoretical ergotism possibility
- Methylprednisolone pharmacokinetic interaction
- Theophylline co-administration
- Warfarin pharmacodynamic interaction
- Effect on terfenadine pharmacokinetics
Contraindications
- Hypersensitivity to Azithromycin or macrolide antibiotics
- Co-administration of ergot derivatives
- Patients with hepatic diseases
Side Effects
- Low incidence of side-effects
- Majority gastrointestinal in origin
- Nausea
- Abdominal discomfort
- Vomiting
- Flatulence
- Diarrhea
- Allergic reactions
- Rare reports of serious hypersensitivity reactions
- Elevations in liver transaminases
- Cholestatic jaundice cases
- Transient mild reductions in neutrophil counts
- Reversible hearing impairment in some patients
Pregnancy & Lactation
- Pregnancy Category B
- Demonstrated safety in animal reproduction studies
- Lack of adequate and well-controlled studies in pregnant women
- Caution advised for nursing women
Precautions & Warnings
- Rare serious allergic reactions
- Reported cases of angioneurotic edema and anaphylaxis
- Caution in severe renal impairment
- Avoid use in hepatic impairment
Use in Special Populations
- No dose adjustment in mild renal impairment
- Caution in severe renal impairment
- Avoid use in hepatic impairment
- No effect on ability to drive or operate machinery
Overdose Effects
- Typical symptoms of overdosage
- Gastric lavage and general supportive measures indicated
Storage Conditions
- Dry place away from light and heat
- Keep out of the reach of children
Chemical Structure
- Molecular formula : C38H72N2O12
- Chemical structure image
Common Questions about Hyzith 200 mg/5 ml Suspension
- Definition of Hyzith 200 mg/5 ml Syrup
- Uses of Hyzith 200 mg/5 ml Syrup
- Side effects of Hyzith 200 mg/5 ml Syrup
- Instructions for storage and disposal of Hyzith 200 mg/5 ml Syrup
- Possibility of diarrhea as a side effect
- Safety of Hyzith 200 mg/5 ml Syrup
- Classification as an antibiotic
- Instructions if no improvement after taking Hyzith 200 mg/5 ml Syrup
- Quick Tips
Relevance
- Clinical use
- Pharmacokinetics
- Administration procedures
- Side effect management
- Patient population considerations
- Chemical composition
- Storage and disposal recommendations