Macrobac 200 mg/5 ml (Powder for Suspension)
15 ml bottle: ৳ 85.26
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Concord pharmaceuticals ltd |
| Also available as |
Indications
- Lower respiratory tract infections treatment
- Upper respiratory tract infections treatment
- Otitis media treatment
- Skin and soft tissue infections treatment
- Treatment of non-gonococcal urethritis in men and women
- Treatment of cervicitis due to Chlamydia trachomatis
Pharmacology
- Oral administration
- Absorption on empty stomach
- Time to peak concentration in adults
- High concentration in phagocytes
- Active transport to site of infection
- Ion trapping effect
- High lipid solubility
- Plasma concentration decline pattern
- Mean apparent plasma clearance
- Terminal elimination half-life
- Biliary excretion as major elimination route
- Microbial protein synthesis inhibition
- Affected microorganisms
- In vitro and clinical activity against specific microorganisms
Dosage
- Adult oral dosage regimen
- Children oral dosage regimen
- Specific dosage for sexually transmitted diseases
- Recommended Azithromycin injection dosage for adult patients with community-acquired pneumonia
- Recommended Azithromycin injection dosage for adult patients with pelvic inflammatory disease
Administration
- Suspension reconstitution procedure
- Preferable timing in relation to meals
Interaction
- Instructions for taking it with antacids
- Pharmacokinetic interaction with carbamazepine
- Possible interference with cyclosporin metabolism
- Reported effect on digoxin metabolism
- Theoretical contraindication with ergot derivatives
- Pharmacokinetic interaction study with methylprednisolone
- Need for theophylline levels monitoring
- Pharmacodynamic interaction study with warfarin
- Effect on the pharmacokinetics of terfenadine
Contraindications
- Hypersensitivity to Azithromycin or macrolide antibiotics
- Co-administration with ergot derivatives
- Patients with hepatic diseases
Side Effects
- Low incidence of side-effects
- Mild to moderate in severity
- Gastrointestinal side-effects observed
- Allergic reactions including rash and photosensitivity
- Rare reports of serious hypersensitivity reactions
- Reversible elevations in liver transaminases
- Rare cases of cholestatic jaundice
- Transient mild reductions in neutrophil counts
- Reversible hearing impairment with higher doses
Pregnancy & Lactation
- Pregnancy Category B
- Demonstrated lack of harm to the fetus in animal studies
- No adequate and well-controlled studies in pregnant women
- Caution in use during pregnancy
- Unknown secretion in breast milk
- Caution in administering to nursing women
Precautions & Warnings
- Rare serious allergic reactions reported
- Reports of recurrent symptoms
- Caution and observation needed
Use in Special Populations
- No dose adjustment needed in mild renal impairment
- Caution in using in more severe renal impairment
- Inadvisable use in patients with hepatic disease
- No evidence of effect on ability to drive or operate machinery
Overdose Effects
- Absence of specific data on overdosage with Macrobac
- Typical symptoms of overdosage with macrolide antibiotics
- Need for general supportive measures
Storage Conditions
- Preference for dry place away from light and heat
- Necessity to keep out of children's reach
Chemical Structure
- Molecular Formula : C38H72N2O12
- Chemical Structure visual reference
Common Questions
- Definition and action of Macrobac 200 mg/5 ml Syrup
- Uses of Macrobac 200 mg/5 ml Syrup
- Side effects of Macrobac 200 mg/5 ml Syrup
- Instructions for storage and disposal of Macrobac 200 mg/5 ml Syrup
- Possibility of diarrhea as a side effect
- Safety and antibiotic class of Macrobac 200 mg/5 ml Syrup
- Course completion importance and precautions
- Quick tips for taking Macrobac 200 mg/5 ml Syrup