Macrobac 200 mg/5 ml (Powder for Suspension)

Indications

• Lower respiratory tract infections treatment
• Upper respiratory tract infections treatment
• Otitis media treatment
• Skin and soft tissue infections treatment
• Treatment of non-gonococcal urethritis in men and women
• Treatment of cervicitis due to Chlamydia trachomatis

Pharmacology

• Oral administration
• Absorption on empty stomach
• Time to peak concentration in adults
• High concentration in phagocytes
• Active transport to site of infection
• Ion trapping effect
• High lipid solubility
• Plasma concentration decline pattern
• Mean apparent plasma clearance
• Terminal elimination half-life
• Biliary excretion as major elimination route
• Microbial protein synthesis inhibition
• Affected microorganisms
• In vitro and clinical activity against specific microorganisms

Dosage

• Adult oral dosage regimen
• Children oral dosage regimen
• Specific dosage for sexually transmitted diseases
• Recommended Azithromycin injection dosage for adult patients with community-acquired pneumonia
• Recommended Azithromycin injection dosage for adult patients with pelvic inflammatory disease

Administration

• Suspension reconstitution procedure
• Preferable timing in relation to meals

Interaction

• Instructions for taking it with antacids
• Pharmacokinetic interaction with carbamazepine
• Possible interference with cyclosporin metabolism
• Reported effect on digoxin metabolism
• Theoretical contraindication with ergot derivatives
• Pharmacokinetic interaction study with methylprednisolone
• Need for theophylline levels monitoring
• Pharmacodynamic interaction study with warfarin
• Effect on the pharmacokinetics of terfenadine

Contraindications

• Hypersensitivity to Azithromycin or macrolide antibiotics
• Co-administration with ergot derivatives
• Patients with hepatic diseases

Side Effects

• Low incidence of side-effects
• Mild to moderate in severity
• Gastrointestinal side-effects observed
• Allergic reactions including rash and photosensitivity
• Rare reports of serious hypersensitivity reactions
• Reversible elevations in liver transaminases
• Rare cases of cholestatic jaundice
• Transient mild reductions in neutrophil counts
• Reversible hearing impairment with higher doses

Pregnancy & Lactation

• Pregnancy Category B
• Demonstrated lack of harm to the fetus in animal studies
• No adequate and well-controlled studies in pregnant women
• Caution in use during pregnancy
• Unknown secretion in breast milk
• Caution in administering to nursing women

Precautions & Warnings

• Rare serious allergic reactions reported
• Reports of recurrent symptoms
• Caution and observation needed

Use in Special Populations

• No dose adjustment needed in mild renal impairment
• Caution in using in more severe renal impairment
• Inadvisable use in patients with hepatic disease
• No evidence of effect on ability to drive or operate machinery

Overdose Effects

• Absence of specific data on overdosage with Macrobac
• Typical symptoms of overdosage with macrolide antibiotics
• Need for general supportive measures

Storage Conditions

• Preference for dry place away from light and heat
• Necessity to keep out of children's reach

Chemical Structure

• Molecular Formula : C38H72N2O12
• Chemical Structure visual reference

Common Questions

• Definition and action of Macrobac 200 mg/5 ml Syrup
• Uses of Macrobac 200 mg/5 ml Syrup
• Side effects of Macrobac 200 mg/5 ml Syrup
• Instructions for storage and disposal of Macrobac 200 mg/5 ml Syrup
• Possibility of diarrhea as a side effect
• Safety and antibiotic class of Macrobac 200 mg/5 ml Syrup
• Course completion importance and precautions
• Quick tips for taking Macrobac 200 mg/5 ml Syrup

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