Macrozith 200 mg/5 ml (Powder for Suspension)

15 ml bottle: ৳ 95.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Silva pharmaceuticals ltd
Also available as
Macrozith 250 mg capsule Macrozith 500 mg tablet

Indications

  • Lower respiratory tract infections
  • Upper respiratory tract infections
  • Sinusitis
  • Pharyngitis/tonsillitis
  • Otitis media
  • Skin and soft tissue infections
  • Non-gonococcal urethritis
  • Cervicitis

Pharmacology

  • Oral administration
  • Time to peak concentration
  • Absorption on an empty stomach
  • High concentration in phagocytes
  • Biliary excretion
  • Microbial protein synthesis interference
  • Activity against gram-positive and gram-negative microorganisms
  • High tissue concentration

Dosage

  • Adult oral dosage: 500mg once daily for 3 days
  • Adult IV dosage: 500mg single daily dose for at least two days
  • Pediatric dosages based on body weight

Administration

  • Reconstitution of suspension
  • Preferably taken 1 hour before or 2 hours after a meal

Interaction

  • Interaction with antacids
  • Cyclosporine metabolism interference
  • Effect on digoxin metabolism
  • Potential ergotism with ergot derivatives
  • Methylprednisolone pharmacokinetic interaction

Contraindications

  • Hypersensitivity to Azithromycin or macrolide antibiotics
  • Co-administration of ergot derivatives
  • Hepatic diseases

Side Effects

  • Gastrointestinal side effects
  • Allergic reactions
  • Reversible liver transaminase elevations
  • Rare cases of cholestatic jaundice
  • Transient mild reductions in neutrophil counts
  • Reversible hearing impairment (with prolonged high doses)

Pregnancy & Lactation

  • Pregnancy category
  • No well-controlled studies in pregnant women
  • Caution in nursing women

Precautions & Warnings

  • Rare serious allergic reactions
  • Angioneurotic edema reports

Use in Special Populations

  • No dose adjustment for mild renal impairment
  • Caution with severe renal impairment
  • Avoid in hepatic impairment

Overdose Effects

  • Typical symptoms of macrolide antibiotic overdosage
  • General supportive measures

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C38H72N2O12
  • Chemical Structure: Image available

Common Questions about Macrozith 200 mg/5 ml Suspension

  • Action of the syrup
  • Uses of the syrup
  • Side effects of the syrup
  • Storage and disposal instructions
  • Potential diarrhea cause
  • Safety at prescribed doses
  • Classification as an antibiotic
  • Consultation if no improvement in symptoms

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