Odazyth 200 mg/5 ml (Powder for Suspension)

Title

• Odazyth 200 mg/5 ml Suspension

Categories

• Medicine
• Pharmaceutical

Description

• Odazyth is indicated for infections (caused by susceptible organisms) in lower respiratory tract infections including bronchitis and pneumonia, in upper respiratory tract infections including sinusitis and pharyngitis/tonsillitis, in otitis media, and in skin and soft tissue infections. In sexually transmitted diseases in men and women, Odazyth is indicated in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.
• Azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids. It is readily absorbed; its absorption is greater on an empty stomach. Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms. Due to the high concentration in phagocytes, azithromycin is actively transported to the site of infection. During active phagocytosis, large concentrations of azithromycin are released. The concentration of azithromycin in the tissues can be over 50 times higher than in plasma. This is due to ion trapping and the high lipid solubility.
• Oral dosage for adults: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days may also be given. Children and intravenous dosage recommendations are also provided.
• Reconstitution procedure of suspension: Shake the bottle well to loosen the powder; Add boiled and cooled water up to the water mark of the bottle label; Shake until powder is completely mixed with water. Azithromycin should be taken at least 1 hour before or 2 hours after meal.
• Antacid interaction, cyclosporin interaction, digoxin interaction, ergot derivatives interaction, methylprednisolone interaction, theophylline interaction, warfarin interaction, terfenadine interaction, contraindications, side effects, pregnancy and lactation, precautions and warnings, use in special populations, overdose effects, and storage conditions are also provided.
• Pregnancy Category of Azithromycin is B. Animal reproduction studies have demonstrated that Azithromycin has no evidence of harm to the fetus. There are no adequate and well controlled studies in pregnant women. Since animal reproduction studies are not always predictive of human response, Azithromycin should be used during pregnancy only if adequate alternatives are not available. It is not known whether Azithromycin is secreted in breast milk. So, caution should be exercised when Azithromycin is administered to nursing women.
• As with erythromycin and other macrolides, rare serious allergic reactions, including angioneurotic oedema and anaphylaxis, has been reported. Some of these reactions with azithromycin have resulted in recurrent symptoms and required a long period of observation and treatment.
• No data on overdosage with Odazyth. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhea. Gastric lavage and general supportive measures are indicated.
• Keep in a dry place away from light and heat. Keep out of the reach of children.
• Molecular Formula: C38H72N2O12. Chemical Structure of Azithromycin Dihydrate is also provided.

Dimensions

Color options

Functions

• Prevention of synthesis of essential proteins required by bacteria to carry out vital functions
• Treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections

Materials

• Azithromycin

Technical specifications

• Oral dosage for adults: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days.
• Reconstitution procedure of suspension: Shake the bottle well to loosen the powder; Add boiled and cooled water up to the water mark of the bottle label; Shake until powder is completely mixed with water.
• Molecular Formula: C38H72N2O12. Chemical Structure of Azithromycin Dihydrate is also provided.

Design elements

Usability features

Dosage

• 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days for adults.
• Intravenous dosage recommendations for the treatment of adult patients with community-acquired pneumonia and pelvic inflammatory disease are also provided. No safety and effectiveness data for children or adolescents under 16 years.

Interaction

• Antacid interaction, cyclosporin interaction, digoxin interaction, ergot derivatives interaction, methylprednisolone interaction, theophylline interaction, warfarin interaction, terfenadine interaction

Contraindications

• Hypersensitivity to Azithromycin or any other macrolide antibiotic
• Co-administration of ergot derivatives
• Patients with hepatic diseases

Side effects

• Gastrointestinal side-effects including nausea, abdominal discomfort, vomiting, flatulence, diarrhea, and loose stools
• Allergic reactions such as rash or photosensitivity
• Rare reports of serious hypersensitivity reactions
• Reversible elevations in liver transaminases
• Rare cases of cholestatic jaundice
• Transient mild reductions in neutrophil counts
• Reversible hearing impairment in some patients

Pregnancy lactation

• Pregnancy Category of Azithromycin is B. Animal reproduction studies have demonstrated that Azithromycin has no evidence of harm to the fetus. There are no adequate and well controlled studies in pregnant women.
• Caution should be exercised when Azithromycin is administered to nursing women.

Precautions warnings

• Rare serious allergic reactions, including angioneurotic oedema and anaphylaxis, have been reported
• No effect on a patient’s ability to drive or operate machinery
• Caution should be exercised in using azithromycin in patients with more severe renal impairment
• Azithromycin should not be used in patients with hepatic disease

Special populations

• No dose adjustment is needed in patients with mild renal impairment
• No data regarding azithromycin in patients with more severe renal impairment, thus caution should be exercised in using azithromycin in these patients
• There is no evidence to suggest that azithromycin may have an effect on a patient’s ability to drive or operate machinery

Overdose effects

• No data on overdosage with Odazyth. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhea. Gastric lavage and general supportive measures are indicated.

Storage conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Chemical structure

• Molecular Formula: C38H72N2O12. Chemical Structure of Azithromycin Dihydrate is also provided.

Common questions

• What is Odazyth 200 mg/5 ml Syrup?
• What are the uses of Odazyth 200 mg/5 ml Syrup?
• What are the Side Effects of Odazyth 200 mg/5 ml Syrup?
• What are the instructions for storage and disposal Odazyth 200 mg/5 ml Syrup?
• Can the use of Odazyth 200 mg/5 ml Syrup cause diarrhea?
• Is Odazyth 200 mg/5 ml Syrup safe?
• Is Odazyth 200 mg/5 ml Syrup an antibiotic?
• What if I don't get better even after taking Odazyth 200 mg/5 ml Syrup?
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