Penalox 200 mg/5 ml (Powder for Suspension)

15 ml bottle: ৳ 95.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Rephco pharmaceuticals ltd
Also available as
Penalox 500 mg capsule

Form and Strength

  • 200 mg/5 ml Suspension
  • 500 mg Oral Tablet
  • 500 mg Injection

Indications

  • Lower respiratory tract infections
  • Upper respiratory tract infections
  • Otitis media
  • Skin and soft tissue infections
  • Sexually transmitted diseases in men and women

Pharmacology

  • Absorbed orally
  • Peak concentration in adults: 2.1 to 3.2 hours
  • High concentration in phagocytes
  • Bacteriostatic levels in infected tissue for several days
  • Active against aerobic and facultative gram-positive/negative microorganisms

Dosage

  • Adult: 500 mg once daily orally for 3 days
  • Children: 10 mg/kg body weight once daily for 3 days
  • Azithromycin Injection for IV Infusion: 500 mg as a single daily dose

Reconstitution procedure

  • Shake the bottle well to loosen the powder
  • Add boiled and cooled water up to the water mark of the bottle label
  • Shake until powder is completely mixed with water

Interaction

  • Antacid: Take at least 1 hour before or 2 hours after
  • Carbamazepine: No significant effect on plasma levels
  • Cyclosporin: Caution before co-administration
  • Digoxin: Monitor digoxin levels
  • Ergot derivatives: Avoid co-administration
  • Methylprednisolone: No significant effect
  • Theophylline: No evidence of pharmacokinetic interaction
  • Warfarin: Did not alter the anticoagulant effect
  • Terfenadine: Did not affect the pharmacokinetics

Contraindications

  • Hypersensitive to Azithromycin or macrolide antibiotic
  • Co-administration of ergot derivatives
  • Patients with hepatic diseases

Side Effects

  • Gastrointestinal side-effects
  • Allergic reactions such as rash or photosensitivity
  • Rare reports of serious hypersensitivity reactions
  • Elevations in liver transaminases
  • Cholestatic jaundice
  • Transient mild reductions in neutrophil counts
  • Reversible hearing impairment

Pregnancy & Lactation

  • Pregnancy Category B
  • No evidence of harm to the fetus in animal reproduction studies
  • Use during pregnancy if adequate alternatives are not available
  • Caution when administered to nursing women

Precautions & Warnings

  • Rare serious allergic reactions reported
  • Caution in patients with renal impairment
  • Not recommended in patients with hepatic disease
  • No evidence of effect on ability to drive or use machines

Overdose Effects

  • Symptoms may include hearing loss, severe nausea, vomiting, and diarrhea
  • General supportive measures are indicated

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C38H72N2O12
  • Chemical Structure

Commonly Asked Questions

  • What is Penalox 200 mg/5 ml Syrup?
  • Uses of Penalox 200 mg/5 ml Syrup
  • Side Effects of Penalox 200 mg/5 ml Syrup
  • Storage and disposal instructions for Penalox 200 mg/5 ml Syrup
  • Diarrhea as a potential side effect
  • Safety of Penalox 200 mg/5 ml Syrup
  • Penalox 200 mg/5 ml Syrup as an antibiotic
  • When to inform the doctor if no improvement is noticed
  • Quick Tips for usage

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