Ranzith 200 mg/5 ml (Powder for Suspension)
15 ml bottle: ৳ 85.26
Medicine Details
| Category | Details |
|---|---|
| Generic | Azithromycin dihydrate |
| Company | Rangs pharmaceuticals ltd |
| Also available as |
Title
- Ranzith 200 mg/5 ml Syrup
Categories
- Medicine
- Antibiotic
- Suspension
Description
- Ranzith is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, skin and soft tissue infections, and sexually transmitted diseases caused by Chlamydia trachomatis. It is also used for community-acquired pneumonia, pharyngitis/tonsillitis, and prevention of infections.
Dosage form
- Oral suspension
Dosage strength
- 200 mg/5 ml
Pharmacology
- Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms, interfering with microbial protein synthesis. It is readily absorbed and has a prolonged terminal half-life, allowing for a large single dose administration.
Absorption time
- 2.1 to 3.2 hours for oral dosage forms
Tissue concentration
- Over 50 times higher than in plasma due to ion trapping and high lipid solubility
Microbiology activity
- Active against a wide range of microorganisms including Staphylococcus aureus, Streptococcus pneumoniae, Haemophilus influenzae, Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma pneumoniae, Bordetella pertussis, Legionella pneumophila, anaerobic microorganisms, and more.
Adult dosage recommendation
- 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days.
Pediatric dosage recommendation
- 10 mg/kg body weight once daily for 3 days for child over 6 months. Specific doses for different body weights.
Administration instructions
- Reconstitution procedure of suspension: Shake the bottle well to loosen the powder, add boiled and cooled water up to the water mark of the bottle label, shake until powder is completely mixed with water. Azithromycin should be taken at least 1 hour before or 2 hours after meal.
Interaction with antacids
- Azithromycin should be taken at least 1 hour before or 2 hours after the antacid.
Contraindications
- Hypersensitivity to Azithromycin or any other macrolide antibiotic, co-administration of ergot derivatives, and hepatic diseases.
Common side effects
- Gastrointestinal origin side-effects including nausea, abdominal discomfort, vomiting, flatulence, diarrhea, and loose stools. Allergic reactions, reversible elevations in liver transaminases, rare reports of serious hypersensitivity reactions, cholestatic jaundice, and hearing impairment.
Pregnancy category
- Category B, caution should be exercised when used during pregnancy, and nursing women should use it cautiously.
Precautions warnings
- Rare serious allergic reactions reported, caution in patients with renal impairment as there are no data regarding azithromycin in patients with severe renal impairment, and it does not affect a patient’s ability to drive or operate machinery.
Storage recommendations
- Keep in a dry place away from light and heat, and out of the reach of children.
Chemical structure
- Molecular Formula: C38H72N2O12
Common questions
- Common questions about Ranzith 200 mg/5 ml Syrup including its action, uses, side effects, storage and disposal instructions, safety, antibiotic classification, and further usage instructions.
Overdose effects
- Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting, and diarrhea. Gastric lavage and general supportive measures are indicated.
Compound summary
- Molecular Formula: C38H72N2O12, Chemical Structure: Image provided
Special population
- No dose adjustment needed in patients with mild renal impairment, caution in patients with hepatic impairment, and no evidence of effect on driving or machine usage.
Medicine color
- Not applicable
Medicine dimensions
- Not applicable
Medicine weight
- Not applicable
Medicine material
- Not applicable
Medicine usability features
- Indicated for various types of infections, active tissue concentration, oral suspension form, and prolonged terminal half-life.
Technical specifications
- Absorption time of 2.1 to 3.2 hours for oral dosage forms and concentrations in tissues over 50 times higher than in plasma due to ion trapping and high lipid solubility.
Design elements
- Suspension reconstitution procedure and chemical structure image provided.
Other
- Caution in patients with hepatic diseases, no dose adjustment needed in patients with mild renal impairment, and no significant effect on a patient's ability to drive or operate machinery.
Medicine functions
- Preventing the synthesis of essential proteins required by bacteria to carry out vital functions.