Respazit 500 mg (Tablet)

Unit Price: ৳ 40.00 (4 x 3: ৳ 480.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Somatec pharmaceuticals ltd
Also available as
Respazit 250 mg capsule Respazit 200 mg suspension

Title

  • Respazit 500 mg Tablet

Categories

  • Antibiotics
  • Macrolide Antibiotics
  • Prescription Medication

Indications

  • Lower respiratory tract infections
  • Upper respiratory tract infections
  • Skin and soft tissue infections
  • Non-gonococcal urethritis
  • Cervicitis
  • Pharyngitis/Tonsillitis
  • Otitis media
  • Bronchitis
  • Pneumonia
  • Sinusitis

Pharmacology

  • Acid-stable
  • Oral administration
  • Time to peak concentration
  • High concentration in phagocytes
  • Active phagocytosis
  • Tissue concentration
  • Bacteriostatic levels maintenance
  • Plasma clearance
  • Half-life
  • Biliary excretion
  • Microbial protein synthesis inhibition
  • Nucleic acid synthesis not affected
  • Activity against aerobic and facultative gram-positive microorganisms
  • Activity against aerobic and facultative gram-negative microorganisms
  • Activity against other microorganisms
  • Activity against anaerobic microorganisms

Dosage

  • Oral: Adult dosage: 500mg for 3 days or 500mg on day 1 followed by 250mg on days 2-5
  • Children:
    • 10 mg/kg for child over 6 months
    • 200 mg for body weight 15-25 kg
    • 300 mg for body weight 26-35 kg
    • 400 mg for body weight 36-45 kg
    • 500 mg for typhoid fever
  • Azithromycin Injection (For IV Infusion only):
    • 500 mg as a single daily dose for at least two days
    • 500 mg as a single daily dose for one or two days for pelvic inflammatory disease in adults
    • Not established in children or adolescents under 16 years

Administration

  • Reconstitution procedure of suspension
  • Shake well before use
  • Take at least 1 hour before or 2 hours after meal

Interaction

  • Antacid interaction
  • Carbamazepine interaction
  • Cyclosporin interaction
  • Digoxin interaction
  • Ergot derivatives interaction
  • Methylprednisolone interaction
  • Theophylline interaction
  • Warfarin interaction
  • Terfenadine interaction

Contraindications

  • Hypersensitivity to Azithromycin or macrolide antibiotics
  • Co-administration of ergot derivatives
  • Hepatic diseases

Side Effects

  • Gastrointestinal side-effects
  • Allergic reactions
  • Reversible elevations in liver transaminases
  • Rare cases of serious hypersensitivity reactions
  • Cholestatic jaundice
  • Transient mild reductions in neutrophil counts
  • Hearing impairment in high doses

Pregnancy & Lactation

  • Pregnancy Category B
  • No evidence of harm to the fetus in animal studies
  • Caution in use during pregnancy
  • Unknown secretion in breast milk
  • Caution when administered to nursing women

Precautions & Warnings

  • Rare serious allergic reactions
  • Angioneurotic oedema
  • Anaphylaxis
  • Long period of observation and treatment for severe allergic reactions

Use in Special Populations

  • No dose adjustment in mild renal impairment
  • Caution in more severe renal impairment
  • Not to be used in hepatic impairment
  • No effect on ability to drive or use machinery

Overdose Effects

  • Typical symptoms of macrolide antibiotic overdosage
  • Supportive measures recommended

Storage Conditions

  • Dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C38H72N2O12
  • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-100-azithromycin-dihydrate-chemical-structure-tFo4BQqfsRzQwcODCGo2.svg

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