Ribozith 200 mg/5 ml (Powder for Suspension)

Indications

• Lower respiratory tract infections
• Upper respiratory tract infections
• Otitis media
• Skin and soft tissue infections
• Sexually transmitted diseases

Pharmacology

• Readily absorbed orally
• Greater absorption on empty stomach
• High concentration in phagocytes
• Active transport to site of infection
• Bacteriostatic levels maintained for several days
• Biliary excretion as major elimination route

Dosage

• 500 mg once daily orally for adults
• 10 mg/kg body weight once daily for children over 6 months
• 500 mg as single daily dose by intravenous route for adults with pelvic inflammatory disease
• No data for safety and effectiveness in children under 16 years

Administration

• Reconstitution procedure for suspension
• Take at least 1 hour before or 2 hours after meal

Interaction

• Interaction with antacids
• Potential interference with cyclosporin metabolism
• Reported impairment of digoxin metabolism
• Avoid co-administration with ergot derivatives
• No significant effect on theophylline levels
• No alteration of warfarin's anticoagulant effect
• No significant effect on terfenadine's pharmacokinetics

Contraindications

• Hypersensitivity to Azithromycin or macrolide antibiotics
• Co-administration with ergot derivatives
• Hepatic diseases

Side Effects

• Low incidence of side-effects
• Majority gastrointestinal in origin
• Allergic reactions including rash and photosensitivity
• Reversible elevations in liver transaminases
• Rare cases of serious hypersensitivity reactions
• Rare instances of cholestatic jaundice
• Transient mild reductions in neutrophil counts
• Reversible hearing impairment at higher doses for prolonged periods

Pregnancy & Lactation

• Category B
• No evidence of harm to fetus in animal studies
• Caution in use during pregnancy and lactation

Precautions & Warnings

• Rare serious allergic reactions reported
• Long period of observation and treatment required in some cases

Use in Special Populations

• No dose adjustment needed in mild renal impairment
• Not recommended in patients with hepatic disease
• No evidence of effect on ability to drive or use machines

Overdose Effects

• Typical symptoms include hearing loss, severe nausea, vomiting, and diarrhea
• Gastric lavage and supportive measures indicated

Storage Conditions

• Keep in dry place away from light and heat
• Keep out of reach of children

Chemical Structure

• Molecular Formula: C38H72N2O12
• Chemical Structure Image: URL

Common Questions

• What is Ribozith 200 mg/5 ml Syrup?
• What are the uses of Ribozith 200 mg/5 ml Syrup?
• What are the Side Effects of Ribozith 200 mg/5 ml Syrup?
• Instructions for storage and disposal
• Adverse effect on diarrhea
• Safety of Ribozith 200 mg/5 ml Syrup
• Classification as antibiotic
• When to consult if no improvement
• Quick Tips for usage

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