Tridosil 500 mg (Tablet)

Indications

• Lower respiratory tract infections treatment
• Upper respiratory tract infections treatment
• Otitis media treatment
• Skin and soft tissue infections treatment
• Treatment of non-gonococcal urethritis
• Treatment of cervicitis due to Chlamydia trachomatis

Pharmacology

• Oral administration
• Rapid absorption on empty stomach
• High concentration in phagocytes
• Time to peak concentration in adults: 2.1 to 3.2 hours
• Half-life allows large single dose administration
• Biliary excretion as major elimination route

Dosage

• Adult oral dosage: 500mg once daily for 3 days
• Adult oral dosage for sexually transmitted diseases: 1gm single dose or 500mg once on day 1, followed by 250mg daily for 2 days
• Oral dosage for children based on body weight
• Azithromycin injection for IV infusion in adult patients with community-acquired pneumonia
• Oral dose administration following IV therapy
• No established safety and effectiveness of IV use in children or adolescents under 16 years

Administration

• Reconstitution procedure for suspension
• Shake bottle to loosen the powder
• Add boiled and cooled water as per label mark
• Shake until powder completely mixed with water
• Take at least 1 hour before or 2 hours after meal

Interaction

• Interaction with antacids
• Potential interaction with carbamazepine
• Caution with co-administration of cyclosporin
• Potential impairment of digoxin metabolism
• Avoid co-administration with ergot derivatives
• No significant pharmacokinetic interaction with methylprednisolone
• Co-administration with theophylline typically does not lead to pharmacokinetic interaction
• Co-administration with warfarin did not alter anticoagulant effect
• No significant effect on terfenadine pharmacokinetics

Contraindications

• Hypersensitivity to azithromycin or macrolide antibiotics
• Co-administration with ergot derivatives
• Patients with hepatic diseases

Side Effects

• Low incidence of side-effects
• Most side-effects observed were mild to moderate
• Gastrointestinal side-effects: nausea, vomiting, diarrhea, etc.
• Allergic reactions: rash, photosensitivity
• Reversible elevations in liver transaminases
• Rare cases of cholestatic jaundice
• Rare cases of transient mild reductions in neutrophil counts
• Cases of reversible hearing impairment in investigational studies

Pregnancy & Lactation

• Pregnancy Category B
• No evidence of harm to fetus in animal reproduction studies
• Caution required during pregnancy if adequate alternatives not available
• Caution for nursing women due to unknown secretion in breast milk

Precautions & Warnings

• Rare reports of serious allergic reactions
• Recurrence of symptoms in some allergic reactions

Use in Special Populations

• No dose adjustment needed in patients with mild renal impairment
• Caution in using azithromycin in patients with severe renal impairment
• Not recommended for patients with hepatic disease
• No evidence of effect on driving or using machinery

Overdose Effects

• Typical symptoms of overdosage with macrolide antibiotics
• Including hearing loss, severe nausea, vomiting, and diarrhea
• Indicated treatment: gastric lavage and general supportive measures

Storage Conditions

• Store in a dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C38H72N2O12

Common Questions about Tridosil 500 mg Tablet

• Action of Tridosil 500 mg Tablet in preventing synthesis of essential proteins in bacteria
• Uses of Tridosil 500 mg Tablet: community-acquired pneumonia, pharyngitis, skin and soft tissue infections
• Side effects of Tridosil 500 mg Tablet: diarrhea, dry or scaly skin, abdominal pain, etc.
• Storage and disposal instructions for Tridosil 500 mg Tablet
• Possibility of diarrhea as a side effect and its management
• Safety of Tridosil 500 mg Tablet at prescribed doses
• Macrolide antibiotic classification of Tridosil 500 mg Tablet
• Directions for informing doctor if no improvement after taking Tridosil 500 mg Tablet

Related Brands

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