Vinzam 500 mg (Tablet)

Unit Price: ৳ 45.00 (3 x 4: ৳ 540.00)
Strip Price: ৳ 180.00

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Ad din pharmaceuticals ltd
Also available as
Vinzam 200 mg suspension

Title

  • Vinzam 500 mg Tablet

Categories

  • Medicine
  • Antibiotic
  • Pharmaceutical

Description

  • Vinzam is indicated for infections in lower respiratory tract infections, upper respiratory tract infections, otitis media, skin and soft tissue infections, and sexually transmitted diseases.
  • Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and interfering with microbial protein synthesis.
  • Vinzam is well tolerated with a low incidence of side-effects. Most side-effects observed were mild to moderate in severity.

Dosage

  • 500 mg once daily orally for 3 days
  • 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days

Administration

  • Azithromycin should be taken at least 1 hour before or 2 hours after meal.
  • Reconstitution procedure of suspension: Shake the bottle well to loosen the powder, Add boiled and cooled water up to the water mark of the bottle label, Shake until powder is completely mixed with water.

Interaction

  • In patients receiving azithromycin and antacids, azithromycin should be taken at least 1 hour before or 2 hours after the antacid.
  • Vinzam and warfarin may be co-administered, but monitoring of the prothrombin time should be continued as routinely performed.

Contraindications

  • Azithromycin is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic.
  • Co-administration of ergot derivatives and Azithromycin is contraindicated.
  • Azithromycin is contraindicated in patients with hepatic diseases.

Side effects

  • Allergic reactions such as rash or photosensitivity have occurred and there have also been rare reports of serious hypersensitivity reactions.
  • Reversible elevations in liver transaminases have been seen with a frequency similar to the comparative macrolides and penicillins used in clinical trials.

Pregnancy lactation

  • Pregnancy Category of Azithromycin is B.
  • It is not known whether Azithromycin is secreted in breast milk. So, caution should be exercised when Azithromycin is administered to nursing women.

Precautions warnings

  • As with erythromycin and other macrolides, rare serious allergic reactions, including angioneurotic oedema and anaphylaxis, has been reported.

Overdose effects

  • Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea.
  • Gastric lavage and general supportive measures are indicated.

Storage conditions

  • Keep in a dry place away from light and heat.
  • Keep out of the reach of children.

Chemical structure

  • Molecular Formula: C38H72N2O12

Commonly asked questions

  • Vinzam 500 mg Tablet performs its action by preventing the synthesis of essential proteins required by bacteria to carry out vital functions.
  • Vinzam 500 mg Tablet is used for the treatment and prevention of community-acquired pneumonia, pharyngitis/tonsillitis, and skin and soft tissue infections.
  • Yes, the use of Vinzam 500 mg Tablet can cause diarrhea. It is an antibiotic that kills harmful bacteria. However, it also affects the helpful bacteria in your stomach or intestine and causes diarrhea. If you are experiencing severe diarrhea, consult your doctor immediately.

Special populations

  • Use in renal impairment: No dose adjustment is needed in patients with mild renal impairment (creatinine clearance >40 ml/min), but there are no data regarding azithromycin in patients with more severe renal impairment, thus caution should be exercised in using azithromycin in these patients.
  • Use in hepatic impairment: As the liver is the principal route of excretion of azithromycin, it should not be used in patients with hepatic disease.

Pharmacology

  • Azithromycin is acid-stable and can therefore be taken orally with no need of protection from gastric acids.
  • Azithromycin's half-life allows a large single dose to be administered and yet maintain bacteriostatic levels in the infected tissue for several days.
  • Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination.

Indications

  • Vinzam is indicated for infections in lower respiratory tract infections, upper respiratory tract infections, otitis media, and skin and soft tissue infections.
  • Vinzam is indicated in the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.

Full recommended dosage

  • Oral: 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days.
  • Azithromycin Injection (For IV Infusion only): The recommended dose of Azithromycin for injection for the treatment of adult patients with community-acquired pneumonia due to the indicated organisms is 500 mg as a single daily dose by the intravenous route for at least two days.

Antibiotic class

  • Macrolides

Pharmacokinetics

  • Time to peak concentration in adults is 2.1 to 3.2 hours for oral dosage forms.
  • Plasma concentrations of azithromycin declined in a polyphasic pattern with a mean apparent plasma clearance of 630 mL/min and a terminal elimination half life of 68 hours.

Microbiology

  • Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and interfering with microbial protein synthesis.
  • Azithromycin has been shown to be active against most isolates of the following microorganisms, both in vitro and in clinical infections.

Other information

  • Azithromycin should be taken at least 1 hour before or 2 hours after meal.
  • Keep out of the reach of children.

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