Zibac 500 mg/ml (IV Infusion)

500 mg vial: ৳ 461.74

Medicine Details

Category Details
Generic Azithromycin dihydrate
Company Popular pharmaceuticals ltd
Also available as
Zibac 250 mg tablet Zibac 500 mg tablet Zibac 200 mg suspension

Title

Zibac 500 mg/ml Injection

Categories

  • Medicine
  • Antibiotics
  • Infection Treatment

Description

Zibac is indicated for infections in lower respiratory tract, upper respiratory tract, otitis media, sexually transmitted diseases, and skin & soft tissue infections.

Brand

Zibac

Dosage form

Oral, Injection

Dosage strength

500 mg

Administration method

Oral, Intravenous

Indicated for

  • Lower Respiratory Tract Infections
  • Upper Respiratory Tract Infections
  • Otitis Media
  • Skin and Soft Tissue Infections
  • Non-gonococcal Urethritis
  • Cervicitis due to Chlamydia trachomatis

Pharmacology

  • Absorption: Readily absorbed, greater on empty stomach
  • Time to peak concentration: 2.1 to 3.2 hours for oral dosage forms
  • Site of infection transport: Actively transported to the site of infection
  • Half life: 68 hours
  • Microbiology:
    • Active against various microorganisms
    • Betalactamase production has no effect on its activity

Safety warnings

  • Contraindications:
    • Hypersensitivity to Azithromycin or macrolide antibiotics
    • Co-administration with ergot derivatives
    • Patients with hepatic diseases
  • Side effects:
    • Gastrointestinal: nausea, abdominal discomfort, vomiting, flatulence, diarrhea
    • Allergic reactions: rash, photosensitivity
    • Liver transaminases elevation
    • Cholestatic jaundice
    • Transient mild reduction in neutrophil counts
    • Reversible hearing impairment in high doses and prolonged usage

Usage guidelines

  • Adult dosage oral:
    • 500 mg once daily for 3 days
    • 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days
  • Adult dosage injection:
    • Community-acquired pneumonia: 500 mg as a single daily dose for at least two days by intravenous route
    • Pelvic inflammatory disease: 500 mg as a single daily dose for one or two days by intravenous route
  • Pediatric dosage oral:
    • Child over 6 months: 10 mg/kg body weight once daily for 3 days
    • Typhoid fever: 500 mg once daily for 7-10 days

Interaction with other drugs

  • Antacids: Take at least 1 hour before or 2 hours after
  • Carbamazepine: No significant effect observed on plasma levels
  • Cyclosporin: Caution and monitoring required
  • Digoxin: Possibility of raised levels should be monitored
  • Ergot derivatives: Contraindicated for co-administration
  • Methylprednisolone: No significant effect observed on pharmacokinetics
  • Theophylline: No evidence of pharmacokinetic interaction
  • Warfarin: Monitoring of prothrombin time should be continued
  • Terfenadine: No significant changes in cardiac repolarization observed

Pregnancy and lactation

  • Pregnancy category: Category B
  • Reproduction studies: No evidence of harm to the fetus
  • Breastfeeding: Caution advised

Special population use

  • Renal impairment: No dose adjustment needed in mild impairment, caution in severe impairment
  • Hepatic impairment: Contraindicated in patients with hepatic disease
  • Effects on driving: No evidence of effect on ability to drive or operate machinery

Overdose effects

No data available, typical symptoms may include hearing loss, severe nausea, vomiting, and diarrhea

Reconstitution procedure

  • Shake the bottle well to loosen the powder
  • Add boiled and cooled water up to the water mark of the bottle label
  • Shake until powder is completely mixed with water

Storage conditions

Keep in a dry place away from light and heat. Keep out of the reach of children.

Chemical structure

  • Molecular formula: C38H72N2O12
  • Image url: https://medex.com.bd/storage/res/g-res-100-azithromycin-dihydrate-chemical-structure-tFo4BQqfsRzQwcODCGo2.svg

Commonly asked questions

  • About iv infusion: Used for community-acquired pneumonia, pharyngitis/tonsillitis, and skin & soft tissue infections
  • Side effects: Include diarrhea, dry or scaly skin, abdominal pain, and vomiting
  • Storage and disposal instructions: Keep in a cool dry place in its original packaging, away from children and pets
  • Quick tips:
    • Do not skip doses and finish full course of treatment
    • Take 1 hour before or two hours after food
    • Do not take antacids 2 hours before or after
    • Inform doctor if severe diarrhea occurs

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