Zithrin 250 mg (Capsule)

Title

• Zithrin 250 mg Capsule

Categories

• Antibiotics
• Macrolide Antibiotic

Description

• Zithrin is used for infections in lower respiratory tract, upper respiratory tract, otitis media, and skin and soft tissue infections.
• It is indicated for the treatment of non-gonococcal urethritis and cervicitis due to Chlamydia trachomatis.
• Azithromycin acts by binding to the 50S ribosomal subunit of susceptible microorganisms and interfering with microbial protein synthesis.
• The recommended dosage for adults is 500 mg once daily orally for 3 days or 500 mg once on day 1, then 250 mg once on days 2-5 for 4 days. For sexually transmitted diseases caused by Chlamydia trachomatis in adults, the dose is 1 gm given as a single dose or 500 mg once on day 1, followed by 250 mg once daily for next 2 days.
• Reconstitution procedure for suspension involves shaking the bottle well, adding boiled and cooled water, and shaking until powder is completely mixed with water.
• Zithrin has specific drug interactions with antacids, carbamazepine, cyclosporin, digoxin, ergot derivatives, methylprednisolone, theophylline, warfarin, and terfenadine.
• It is contraindicated in patients hypersensitive to Azithromycin or any other macrolide antibiotic, co-administration of ergot derivatives and Azithromycin, and patients with hepatic diseases.
• Common side effects include gastrointestinal discomfort, allergic reactions, reversible elevations in liver transaminases, transient mild reductions in neutrofil counts, and reversible hearing impairment with higher doses.
• Pregnancy Category of Azithromycin is B, and caution should be exercised when administered to nursing women.
• Rare serious allergic reactions including angioneurotic oedema and anaphylaxis have been reported, and caution is advised in patients with renal impairment.
• There is no data on overdosage with Zithrin. Typical symptoms of overdosage with macrolide antibiotics include hearing loss, severe nausea, vomiting and diarrhoea.
• Storage conditions require keeping the product in a dry place away from light and heat, and out of the reach of children.

Dimensions

Color options

Functions

• Treatment of infections
• Prevention of community-acquired pneumonia
• Pharyngitis/tonsillitis treatment
• Skin and soft tissue infection treatment
• Treatment of non-gonococcal urethritis and cervicitis

Materials

Technical specifications

• Molecular Formula: C38H72N2O12
• Chemical Structure: Image of Chemical Structure of Azithromycin Dihydrate

Design elements

Usability features

• Oral administration
• Reconstitution of suspension
• Dosage for adults and children
• Use in patients with renal impairment
• No effect on a patient’s ability to drive or operate machinery

Additional information

• Low incidence of side-effects
• Caution during pregnancy and lactation
• Rare serious allergic reactions reported
• No data on overdosage with Zithrin

Warnings

• Rare serious allergic reactions have been reported
• Caution in patients with renal impairment
• Gastric lavage and general supportive measures indicated in case of overdosage

Storage information

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Pharmacology

• Azithromycin is acid-stable and can be taken orally with no need of protection from gastric acids
• Readily absorbed; greater absorption on an empty stomach
• High concentration in phagocytes; actively transported to the site of infection
• Large concentrations released during active phagocytosis
• Concentration in the tissues can be over 50 times higher than in plasma
• Acts by binding to the 50S ribosomal subunit of susceptible microorganisms, interfering with microbial protein synthesis
• Biliary excretion of azithromycin, predominantly unchanged, is a major route of elimination

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