Clacin 500 mg (Tablet)
Unit Price: ৳ 40.00 (4's pack: ৳ 160.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Medimet pharmaceuticals ltd |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
Inhibits microsomal protein synthesis, active against Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas, more acid-stable than Erythromycin, twice the activity of Erythromycin against H. influenzae, most Gram-negative bacteria are resistant
Dosage & Administration
- Various dosing regimens for different indications in adults and children
- Dosage adjustment required in severe renal impairment with or without coexisting hepatic impairment
- Principally excreted via the liver and kidney
Interaction
- Contraindicated with HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and certain antiarrhythmics
Contraindications
- Known hypersensitivity to clarithromycin, erythromycin, or any macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions ranging from urticaria and mild skin reactions to anaphylaxis
- Taste perversion
- Transient central nervous system side effects including anxiety, dizziness, insomnia, and hallucination
Pregnancy & Lactation
- May be used in neonates and children in appropriate doses
- Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed
- Not recommended in pregnant patients
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Increased risk of all-cause mortality in patients with coronary artery disease one year or more after the end of treatment
- Evaluate patients for Clostridium difficile associated diarrhea (CDAD) if diarrhea occurs
- Exacerbation of myasthenia gravis reported in patients receiving Clacin therapy
Use in Special Populations
- Safety and effectiveness established for specific pediatric indications
- Safety and effectiveness not established in pediatric patients under 6 months of age
Overdose Effects
- Ingestion of large amounts can produce gastro-intestinal symptoms
- Supportive measures and prompt elimination of unabsorbed drug for adverse reactions accompanying overdosage
- Serum levels not expected to be affected appreciably by haemodialysis or peritoneal dialysis
Therapeutic Class
Macrolides
Storage Conditions
Store in a cool and dry place, protected from light & moisture. Reconstituted suspension must be used within 7-14 days depending on storage temperature