Claricin 250 mg (Tablet)
Unit Price: ৳ 30.00 (2 x 4: ৳ 240.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Treatment of acute bacterial exacerbation of chronic bronchitis in adults
- Treatment of acute maxillary sinusitis
- Treatment of community-acquired pneumonia
- Treatment of pharyngitis or tonsillitis
- Treatment of uncomplicated skin and skin structure infections
- Treatment of acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Treatment of Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms
- Binds to the donor site on the 50S subunit of the bacterial ribosome
- Prevents translocation to the donor site
- Active against most Gram-positive bacteria and Chlamydia
- Active against some Gram-negative bacteria and Mycoplasmas
- Twice the activity of Erythromycin against H. influenzae
Dosage & Administration
- Dosage varies for different conditions and age groups
- Combination dosing regimens for H. pylori infection
- Specific dosages for triple and dual therapy for H. pylori infection
- Dosage adjustment for renal and hepatic impairment
Interaction
- Contraindicated with HMG-CoA reductase inhibitors
- Contraindicated with gastroprokinetic agents
- Contraindicated with ergot alkaloids
- Contraindicated with antipsychotics
- Contraindicated with anti-gout agents
Contraindications
- Known hypersensitivity to clarithromycin or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions (ranging from urticaria to anaphylaxis)
- Taste perversion
- Transient central nervous system side effects (anxiety, dizziness, insomnia, hallucination)
Pregnancy & Lactation
- May be used in neonates and children in appropriate doses
- Breast milk from mothers receiving clarithromycin should not be given to infants until treatment is completed
- Not recommended for pregnant patients
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation
- Avoid in patients receiving drugs known to prolong the QT interval
- Discontinue if signs and symptoms of hepatitis occur
- Increased risk of all-cause mortality in patients with coronary artery disease
- Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs
- Exacerbation of myasthenia gravis reported in patients receiving clarithromycin therapy
Use in Special Populations
- Safety and effectiveness established for various conditions in pediatric patients
- Safety not established in pediatric patients under 6 months of age
Overdose Effects
- Ingestion of large amounts can produce gastrointestinal symptoms
- Adverse reactions should be treated by elimination of unabsorbed drug and supportive measures
- Serum levels not expected to be affected by hemodialysis or peritoneal dialysis
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place protected from light and moisture
- Reconstituted suspension must be used within specific timeframes
- Keep out of reach of children