Clarison 500 mg (Tablet)
Unit Price: ৳ 45.00 (10's pack: ৳ 450.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Hudson pharmaceuticals ltd |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the 50S subunit of the bacterial ribosome
- Activity against Gram-positive bacteria and Chlamydia
- Acid-stable nature compared to Erythromycin
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults
- Dosage for acute maxillary sinusitis
- Dosage for community-acquired pneumonia
- Dosage for pharyngitis or tonsillitis
- Dosage for uncomplicated skin and skin structure infections
- Dosage for treatment and prophylaxis of disseminated Mycobacterium avium disease
- Combination dosing regimens for H. pylori infection
- Dosage for pediatric patients
- Dosage adjustments for renal and hepatic impairment
Interaction
- Contraindication with HMG-CoA reductase inhibitors
- Contraindication with gastroprokinetic agents
- Contraindication with ergot alkaloids
- Contraindication with antipsychotics
- Contraindication with anti-gout agents
- Not recommended with antiarrhythmics drugs
Contraindications
- Known hypersensitivity to clarithromycin, erythromycin, or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Appropriate use in neonates and children
- Precaution for breastfeeding mothers
Precautions & Warnings
- Discontinue in case of severe acute hypersensitivity reactions
- Avoid in patients with known QT prolongation
- Discontinue in case of signs and symptoms of hepatitis
- Increased risk in patients with coronary artery disease
- Evaluation for Clostridium difficile associated diarrhea (CDAD) in case of diarrhea
Use in Special Populations
- Safety and effectiveness in pediatric patients
- Precaution for patients under 6 months of age
Overdose Effects
- Gastro-intestinal symptoms with large amounts
- Altered mental status
- Paranoid behaviour
- Hypokalemia
- Hypoxemia
- Prompt elimination of unabsorbed drug and supportive measures for treatment
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry storage
- Protection from light & moisture
- Reconstituted suspension usage timeframe
- Keep out of reach of children