Klabid 250 mg (Tablet)

Unit Price: ৳ 30.00 (2 x 7: ৳ 420.00)
Strip Price: ৳ 210.00

Medicine Details

Category Details
Generic Clarithromycin
Company Unimed unihealth pharmaceuticals ltd
Also available as
Klabid 500 mg tablet Klabid er 500 mg tablet Klabid 125 mg suspension Klaricid 500 mg injection Klabid ds 250 mg suspension

Indications

  • Acute bacterial exacerbation of chronic bronchitis in adults
  • Acute maxillary sinusitis
  • Community-acquired pneumonia
  • Pharyngitis or tonsillitis
  • Uncomplicated skin and skin structure infections
  • Acute otitis media in pediatric patients
  • Treatment and prophylaxis of disseminated mycobacterial infections
  • Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

  • Inhibits microsomal protein synthesis in susceptible organisms
  • Binds to the donor site on the 50S subunit of the bacterial ribosome
  • Active against most Gram-positive bacteria and Chlamydia
  • More acid-stable than Erythromycin
  • Twice the activity of Erythromycin against H. influenzae
  • Resistance in most species of Gram-negative bacteria

Dosage & Administration

  • Dosage varies based on indication and patient age
  • Combination dosing regimens for H. pylori infection
  • Different dosages in renal and hepatic impairment

Interaction

  • Contraindicated with specific medications like HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, and anti-gout agents
  • Not recommended with certain antiarrhythmics drugs

Contraindications

  • Hypersensitivity to clarithromycin, erythromycin, or macrolide antibacterial drugs
  • History of cholestatic jaundice or hepatic dysfunction associated with the prior use of clarithromycin

Side Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Stomatitis
  • Glossitis
  • Headache
  • Allergic reactions
  • Taste perversion
  • Transient central nervous system side effects including anxiety, dizziness, insomnia, and hallucination

Pregnancy & Lactation

  • Suitable for use in neonates and children in appropriate doses
  • Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed
  • Not recommended for pregnant patients

Precautions & Warnings

  • Discontinue if severe acute hypersensitivity reactions occur
  • Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
  • Increased risk of all-cause mortality in patients with coronary artery disease
  • Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs
  • Exacerbation of myasthenia gravis reported in patients receiving Klabid therapy

Use in Special Populations

  • Established safety and effectiveness for various indications in pediatric patients
  • Not studied in MAC patients under the age of 20 months
  • Safety and effectiveness in pediatric patients under 6 months of age not established

Overdose Effects

  • Expected to produce gastrointestinal symptoms in large amounts
  • Reported altered mental status, paranoid behavior, hypokalemia, and hypoxemia with ingestion of high doses
  • Prompt elimination of unabsorbed drug and supportive measures are recommended
  • Serum levels not expected to be appreciably affected by dialysis

Therapeutic Class

  • Macrolides

Storage Conditions

  • Store in a cool and dry place, protected from light and moisture
  • Reconstituted suspension must be used within specified timeframes
  • Keep out of reach of children

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