Klabid 125 mg/5 ml (Powder for Suspension)
70 ml bottle: ৳ 390.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the 50S subunit of the bacterial ribosome
- Prevention of translocation
- Activity against most Gram-positive bacteria
- Activity against Chlamydia, some Gram-negative bacteria and Mycoplasmas
- Greater acid-stability than Erythromycin
- Twice the activity against H. influenzae compared to Erythromycin
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults
- Dosage for acute maxillary sinusitis in adults
- Dosage for community-acquired pneumonia in adults
- Dosage for pharyngitis or tonsillitis in adults
- Dosage for uncomplicated skin and skin structure infections in adults
- Dosage for treatment and prophylaxis of disseminated Mycobacterium avium disease in adults
- Dosage for H. pylori infection in adults
- Dosage for pediatric patients
- Dosage for renal and hepatic impairment
Interaction
- Contraindications with specific medications
- Contradictions with HMG-CoA reductase inhibitors
- Contraindications with gastroprokinetic agents
- Contraindications with ergot alkaloids
- Contraindications with antipsychotics
- Contraindications with anti-gout agents
- Not recommended with antiarrhythmics drugs
Contraindications
- Hypersensitivity to clarithromycin or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Use in neonates and children
- Avoidance of breast milk from mothers receiving Clarithromycin
- Not recommended for pregnant patients
Precautions & Warnings
- Discontinuation upon severe acute hypersensitivity reactions
- Avoidance in patients with known QT prolongation
- Avoidance in patients receiving drugs known to prolong the QT interval
- Discontinuation upon signs and symptoms of hepatitis
- Increased risk of all-cause mortality in patients with coronary artery disease
Use in Special Populations
- Safety and effectiveness in pediatric patients
- Safety and effectiveness in neonates and children
- Use in children and adolescents
- Safety and effectiveness in preventing disseminated Mycobacterium avium complex (MAC) disease
Overdose Effects
- Gastro-intestinal symptoms upon ingestion of large amounts
- Altered mental status
- Paranoid behaviour
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry storage
- Protection from light & moisture
- Specific time frame for reconstituted suspension use
- Keep out of reach of children