Maclar 125 mg/5 ml (Powder for Suspension)
60 ml bottle: ৳ 395.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Techno drugs ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms
- Binds to the donor site on the 50S subunit of the bacterial ribosome
- Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
- More acid-stable than Erythromycin
- Twice the activity of Erythromycin against H. influenzae
Dosage & Administration
- Varied dosages for different conditions in adults
- Combination dosing regimens for H. pylori infection
- Recommended daily dosage for children
- Administration guidelines for renal and hepatic impairment
Interaction
- Contraindicated with specific medications, e.g., HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and certain antiarrhythmics
Contraindications
- Hypersensitivity to clarithromycin or any macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Safe use in neonates and children
- Caution in breastfeeding mothers
- Not recommended during pregnancy
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Discontinuation if signs and symptoms of hepatitis occur
- Increased risk of all-cause mortality in patients with coronary artery disease
- Evaluation for Clostridium difficile associated diarrhea if diarrhea occurs
Use in Special Populations
- Established safety and effectiveness in pediatric patients for various conditions
- Caution in pediatric patients under 6 months of age
Overdose Effects
- Gastrointestinal symptoms expected with large amounts
- Adverse reactions treatment recommendations
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place, protected from light & moisture
- Reconstituted suspension must be used within specific timeframes
- Keep out of reach of children