Remac 500 mg (Tablet)
Unit Price: ৳ 45.00 (1 x 6: ৳ 270.00)
Strip Price: ৳ 270.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of acute bacterial exacerbation of chronic bronchitis in adults
- Treatment of acute maxillary sinusitis
- Treatment of community-acquired pneumonia
- Treatment of pharyngitis or tonsillitis
- Treatment of uncomplicated skin and skin structure infections
- Treatment of acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Treatment of Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms
- Binds to the donor site on the 50S subunit of the bacterial ribosome
- Active against most Gram-positive bacteria and Chlamydia
- More acid-stable than Erythromycin
- Twice the activity of Erythromycin against H. influenzae
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults
- Dosage for acute maxillary sinusitis in adults
- Dosage for community-acquired pneumonia in adults
- Dosage for pharyngitis or tonsillitis in adults
- Dosage for uncomplicated skin and skin structure infections in adults
- Dosage for treatment and prophylaxis of disseminated Mycobacterium avium disease in adults
- Dosage for H. pylori infection in adults
- Dosage for pediatric patients
- Dosage adjustments for renal and hepatic impairment
Interaction
- Contraindicated with HMG-CoA reductase inhibitors
- Contraindicated with gastroprokinetic agents
- Contraindicated with ergot alkaloids
- Contraindicated with antipsychotics
- Contraindicated with anti-gout agents
- Not recommended with certain antiarrhythmics drugs
Contraindications
- Known hypersensitivity to clarithromycin or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Safe for neonates and children in appropriate doses
- Breast milk from mothers receiving Clarithromycin should not be given to infants
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Discontinue if signs and symptoms of hepatitis occur
- Increased risk of all-cause mortality in patients with coronary artery disease
Use in Special Populations
- Safety and effectiveness in pediatric patients
- Use in children and adolescents
Overdose Effects
- Gastro-intestinal symptoms
- Altered mental status
- Paranoid behaviour
- Hypokalemia
- Hypoxemia
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry place
- Protected from light & moisture
- Reconstituted suspension usage within 7-14 days based on storage