Klabex 500 mg (Tablet)
Unit Price: ৳ 40.00 (1 x 6: ৳ 240.00)
Strip Price: ৳ 240.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis in susceptible organisms
- Binds to the donor site on the 50S subunit of the bacterial ribosome
- Active against most Gram-positive bacteria, Chlamydia, some Gram-negative bacteria, and Mycoplasmas
- Twice the activity of Erythromycin against H. influenzae
Dosage & Administration
- Dosage varies for different conditions and age groups
- Combination dosing regimens for H. pylori infection
- Special dosage considerations for renal and hepatic impairment
Drug Interaction
- Contraindicated with HMG-CoA reductase inhibitors, gastroprokinetic agents, ergot alkaloids, antipsychotics, anti-gout agents, and certain antiarrhythmics
Contraindications
- Known hypersensitivity to clarithromycin, erythromycin, or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis and glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Not recommended in pregnant patients
- Caution advised in breastfeeding mothers
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation or receiving certain drugs
- Monitor for signs and symptoms of hepatitis
- Increased risk of all-cause mortality in patients with coronary artery disease
- Evaluate for Clostridium difficile associated diarrhea if diarrhea occurs
- Exacerbation of myasthenia gravis reported
Use in Special Populations
- Safety and effectiveness in pediatric patients established for specific conditions and age groups
- Caution advised in pediatric patients under 6 months of age
Overdose Effects
- Ingestion of large amounts can produce gastro-intestinal symptoms
- Adverse reactions accompanying overdosage should be treated with prompt elimination of unabsorbed drug and supportive measures
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place
- Protected from light & moisture
- Reconstituted suspension must be used within specified timeframes
- Keep out of reach of children