Klaricid 500 mg/vial (IV Injection)
500 mg vial: ৳ 850.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Abbott laboratories ltd pakistan |
| Also available as |
Indications
- Treatment of acute bacterial exacerbation of chronic bronchitis in adults
- Treatment of acute maxillary sinusitis
- Treatment of community-acquired pneumonia
- Treatment of pharyngitis or tonsillitis
- Treatment of uncomplicated skin and skin structure infections
- Treatment of acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Treatment of Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the 50S subunit of the bacterial ribosome
- Prevention of translocation to the donor site
- Activity against most Gram-positive bacteria and Chlamydia
- More acid-stable than Erythromycin
- Twice the activity of Erythromycin against H. influenzae
- Resistance of most species of Gram-negative bacteria to Clarithromycin
Dosage & Administration
- Dosage for different conditions in adults and children
- Combination dosing regimens for H. pylori infection
- Specific dosing recommendation for renal and hepatic impairment
Interaction
- Contraindications with specific medications
- Not recommended in combination with certain antiarrhythmics drugs
Contraindications
- Known hypersensitivity to clarithromycin
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Usage in neonates and children
- Precaution for use in breastfeeding mothers
Precautions & Warnings
- Discontinuation in case of severe acute hypersensitivity reactions
- Avoidance in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Increased risk of all-cause mortality in patients with coronary artery disease
- Evaluation for Clostridium difficile associated diarrhea (CDAD) if diarrhea occurs
Use in Special Populations
- Safety and effectiveness in pediatric patients 6 months and older
- Safety and effectiveness in preventing disseminated Mycobacterium avium complex (MAC) disease in pediatric patients 20 months and older with advanced HIV infection
Overdose Effects
- Expected gastrointestinal symptoms with large ingestion
- Adverse reactions and treatment measures
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry storage
- Protection from light and moisture
- Reconstituted suspension usage within specified timeframes
- Keep out of reach of children