Klarix 250 mg (Tablet)
Unit Price: ৳ 25.00 (1 x 10: ৳ 250.00)
Strip Price: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the bacterial ribosome
- Prevention of translocation to the donor site
- Activity against most Gram-positive bacteria and Chlamydia
- Acid stability
- Activity against H. influenzae
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults
- Dosage for acute maxillary sinusitis in adults
- Dosage for community-acquired pneumonia in adults
- Dosage for pharyngitis or tonsillitis in adults
- Dosage for uncomplicated skin and skin structure infections in adults
- Dosage for treatment and prophylaxis of disseminated mycobacterial infections in adults
- Dosage for H. pylori infection in adults
- Dosage for pediatric patients
- Dosage adjustments for renal and hepatic impairment
Interaction
- Contraindication with HMG-CoA reductase inhibitors
- Contraindication with gastroprokinetic agents
- Contraindication with ergot alkaloids
- Contraindication with antipsychotics
- Contraindication with anti-gout agents
- Not recommended with certain antiarrhythmics
Contraindications
- Known hypersensitivity to macrolide antibacterial drugs
- Known hypersensitivity to clarithromycin or erythromycin
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Use in neonates and children
- Precaution with breast milk
Precautions & Warnings
- Discontinuation for severe acute hypersensitivity reactions
- Avoidance in patients with known QT prolongation
- Increased risk of all-cause mortality in patients with coronary artery disease
- Evaluation for Clostridium difficile associated diarrhea
- Exacerbation of myasthenia gravis
Use in Special Populations
- Safety and effectiveness in pediatric patients aged 6 months and older
- Safety and effectiveness in pediatric patients with advanced HIV infection
- Unestablished safety in pediatric patients under 6 months of age
Overdose Effects
- Production of gastrointestinal symptoms
- Altered mental status
- Paranoid behavior
- Hypokalemia
- Hypoxemia
- Treatment with prompt elimination of unabsorbed drug
Therapeutic Class
Macrolides
Storage Conditions
- Cool and dry storage
- Protection from light and moisture
- Reconstituted suspension usage within 7 days at room temperature
- Reconstituted suspension usage within 14 days when stored in a refrigerator
- Protection from children