Klarix 500 mg (Tablet)
Unit Price: ৳ 40.00 (2 x 3: ৳ 240.00)
Strip Price: ৳ 120.00
Medicine Details
Category | Details |
---|---|
Generic | Clarithromycin |
Company | Incepta pharmaceuticals ltd |
Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibits microsomal protein synthesis
- Binds to the donor site on the 50S subunit of the bacterial ribosome
- Active against most Gram-positive bacteria and Chlamydia
- Better tolerated due to being more acid-stable than Erythromycin
- Twice the activity of Erythromycin against H. influenzae
Dosage & Administration
- Dosage for acute bacterial exacerbation of chronic bronchitis in adults: 250-500 mg every 12 hours for 7-14 days
- Dosage for acute maxillary sinusitis: 500 mg every 12 hours for 14 days
- Dosage for community-acquired pneumonia: 250 mg every 12 hours for 7-14 days
- Dosage for pharyngitis or tonsillitis: 250 mg every 12 hours for 10 days
- Dosage for uncomplicated skin and skin structure infections: 250 mg every 12 hours for 7-14 days
- Combination dosing regimens for H. pylori infection
Interaction
- Contraindicated with HMG-CoA reductase inhibitors
- Contraindicated with gastroprokinetic agents
- Contraindicated with ergot alkaloids
- Contraindicated with antipsychotics
- Contraindicated with anti-gout agents
- Not recommended with antiarrhythmics drugs
Contraindications
- Known hypersensitivity to clarithromycin or any macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Not recommended during pregnancy
- Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed
Precautions & Warnings
- Discontinue if severe acute hypersensitivity reactions occur
- Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
- Discontinue if signs and symptoms of hepatitis occur
- Increased risk of all-cause mortality in patients with coronary artery disease
Use in Special Populations
- Safety and effectiveness in pediatric patients established for various conditions
- Not studied in MAC patients under 20 months
Overdose Effects
- Ingestion may produce gastro-intestinal symptoms
- Prompt elimination of unabsorbed drug and supportive measures required
Therapeutic Class
- Macrolides
Storage Conditions
- Store in a cool and dry place
- Protected from light & moisture
- Reconstituted suspension must be used within 7-14 days based on storage temperature
Related Brands
- Klarix 125 mg/5 ml (Powder for Suspension) - incepta-pharmaceuticals-ltd
- Claricin 125 mg/5 ml (Powder for Suspension) - acme-laboratories-ltd
- Clarimycin 500 mg (Tablet) - amico-laboratories-ltd
- Clarith 500 mg (Tablet) - ibn-sina-pharmaceuticals-ltd
- Clarith 125 mg/5 ml (Powder for Suspension) - ibn-sina-pharmaceuticals-ltd