Klarix 500 mg (Tablet)

Unit Price: ৳ 40.00 (2 x 3: ৳ 240.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Clarithromycin
Company Incepta pharmaceuticals ltd
Also available as
Klarix 250 mg tablet Klarix 125 mg suspension

Indications

  • Acute bacterial exacerbation of chronic bronchitis in adults
  • Acute maxillary sinusitis
  • Community-acquired pneumonia
  • Pharyngitis or tonsillitis
  • Uncomplicated skin and skin structure infections
  • Acute otitis media in pediatric patients
  • Treatment and prophylaxis of disseminated mycobacterial infections
  • Helicobacter pylori infection and duodenal ulcer disease in adults

Pharmacology

  • Inhibits microsomal protein synthesis
  • Binds to the donor site on the 50S subunit of the bacterial ribosome
  • Active against most Gram-positive bacteria and Chlamydia
  • Better tolerated due to being more acid-stable than Erythromycin
  • Twice the activity of Erythromycin against H. influenzae

Dosage & Administration

  • Dosage for acute bacterial exacerbation of chronic bronchitis in adults: 250-500 mg every 12 hours for 7-14 days
  • Dosage for acute maxillary sinusitis: 500 mg every 12 hours for 14 days
  • Dosage for community-acquired pneumonia: 250 mg every 12 hours for 7-14 days
  • Dosage for pharyngitis or tonsillitis: 250 mg every 12 hours for 10 days
  • Dosage for uncomplicated skin and skin structure infections: 250 mg every 12 hours for 7-14 days
  • Combination dosing regimens for H. pylori infection

Interaction

  • Contraindicated with HMG-CoA reductase inhibitors
  • Contraindicated with gastroprokinetic agents
  • Contraindicated with ergot alkaloids
  • Contraindicated with antipsychotics
  • Contraindicated with anti-gout agents
  • Not recommended with antiarrhythmics drugs

Contraindications

  • Known hypersensitivity to clarithromycin or any macrolide antibacterial drugs
  • History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin

Side Effects

  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Stomatitis
  • Glossitis
  • Headache
  • Allergic reactions
  • Taste perversion
  • Transient central nervous system side effects

Pregnancy & Lactation

  • Not recommended during pregnancy
  • Breast milk from mothers receiving Clarithromycin should not be given to infants until treatment is completed

Precautions & Warnings

  • Discontinue if severe acute hypersensitivity reactions occur
  • Avoid in patients with known QT prolongation or receiving drugs known to prolong the QT interval
  • Discontinue if signs and symptoms of hepatitis occur
  • Increased risk of all-cause mortality in patients with coronary artery disease

Use in Special Populations

  • Safety and effectiveness in pediatric patients established for various conditions
  • Not studied in MAC patients under 20 months

Overdose Effects

  • Ingestion may produce gastro-intestinal symptoms
  • Prompt elimination of unabsorbed drug and supportive measures required

Therapeutic Class

  • Macrolides

Storage Conditions

  • Store in a cool and dry place
  • Protected from light & moisture
  • Reconstituted suspension must be used within 7-14 days based on storage temperature

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