Klarix 125 mg/5 ml (Powder for Suspension)
60 ml bottle: ৳ 395.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Clarithromycin |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Indications
- Acute bacterial exacerbation of chronic bronchitis in adults
- Acute maxillary sinusitis
- Community-acquired pneumonia
- Pharyngitis or tonsillitis
- Uncomplicated skin and skin structure infections
- Acute otitis media in pediatric patients
- Treatment and prophylaxis of disseminated mycobacterial infections
- Helicobacter pylori infection and duodenal ulcer disease in adults
Pharmacology
- Inhibition of microsomal protein synthesis
- Binding to the donor site on the 50S subunit of the bacterial ribosome
- Preventing translocation to the donor site
- Activity against most Gram-positive bacteria and Chlamydia
- Acid stability
- Twice the activity against H. influenzae compared to Erythromycin
- Resistance of most species of Gram-negative bacteria
Dosage & Administration
- Adult dosing for various conditions
- Combination dosing regimens for H. pylori infection
- Recommended pediatric dosage for different indications
- Administration in renal and hepatic impairment
Interaction
- Contraindicated with specific medications such as HMG-CoA reductase inhibitors and antiarrhythmics
Contraindications
- Hypersensitivity to clarithromycin or macrolide antibacterial drugs
- History of cholestatic jaundice or hepatic dysfunction associated with prior use of clarithromycin
Side Effects
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Stomatitis
- Glossitis
- Headache
- Allergic reactions
- Taste perversion
- Transient central nervous system side effects
Pregnancy & Lactation
- Use in neonates and children
- Advice against breastfeeding during treatment
- Limited experience in treating pregnant patients
Precautions & Warnings
- Discontinuation in case of severe acute hypersensitivity reactions
- Avoidance in patients with known QT prolongation or receiving specific drugs
- Increased risk of all-cause mortality in patients with coronary artery disease after treatment
- Evaluation for Clostridium difficile associated diarrhea if diarrhea occurs
- Exacerbation of myasthenia gravis
Use in Special Populations
- Safety and effectiveness in pediatric patients 6 months and older for various indications
- Use in prevention of disseminated Mycobacterium avium complex (MAC) disease in pediatric patients 20 months and older with advanced HIV infection
- Unestablished safety and effectiveness in MAC patients under 20 months and under 6 months
Overdose Effects
- Gastro-intestinal symptoms with large ingestion
- Reported case of altered mental status, paranoid behaviour, hypokalemia, and hypoxemia with 8 grams ingestion
- Treatment of adverse reactions with prompt elimination of unabsorbed drug and supportive measures
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry storage
- Protection from light & moisture
- Reconstituted suspension usage timeframe
- Keeping out of reach of children