Amoclav 875 mg+125 mg (Tablet)
Unit Price: ৳ 40.00 (2 x 6: ৳ 480.00)
Strip Price: ৳ 240.00
Medicine Details
Category | Details |
---|---|
Generic | Amoxicillin clavulanic acid |
Company | Techno drugs ltd |
Also available as |
Indications
- Treatment of upper respiratory tract infections
- Treatment of lower respiratory tract infections
- Treatment of genito-urinary tract infections
- Treatment of skin and soft tissue infections
- Treatment of bone and joint infections
- Treatment of other infections
Composition
- 375 mg tablet: Amoxicillin 250 mg as Amoxicillin Trihydrate BP, Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
- 625 mg tablet: Amoxicillin 500 mg as Amoxicillin Trihydrate BP, Clavulanic Acid 125 mg as Diluted Potassium Clavulanate BP
- 1 gm tablet: Amoxicillin 875 mg as Amoxicillin Trihydrate BP, Clavulanic Acid 125 mg Diluted Potassium Clavulanate BP
- Powder for Suspension: 125 mg Amoxicillin Trihydrate BP, 31.25 mg Clavulanic Acid Diluted Potassium Clavulanate BP
- Powder for Suspension (Forte): 400 mg Amoxicillin Trihydrate BP, 57.5 mg Clavulanic Acid Diluted Potassium Clavulanate BP
- 1.2 gm Injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 1 gm), Clavulanate Potassium USP (equivalent to Clavulanic Acid 200 mg)
- 0.6 gm injection: Amoxicillin Sodium BP (equivalent to Amoxicillin 500 mg), Clavulanate Potassium USP (equivalent to Clavulanic Acid 100 mg)
Pharmacology
- Bactericidal activity against Gram-positive & Gram-negative microorganisms
- Broad spectrum of bactericidal activity
- Clavulanic acid inactivates a wide range of beta-lactamase enzymes
Dosage
- Usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours
- For more severe infections, the dose should be increased
- Dosage varies for children based on age and severity of infection
Administration
- Oral dosage form can be taken without regard to meals
- IV injection suitable for intravenous administration only
- IV injection must be administered over 2 minutes or slow intravenous infusion over 30 minutes
Interaction
- Prolongation of bleeding time reported in some patients
- Reduced efficacy of oral contraceptives
- Potential interaction with allopurinol
Contraindications
- History of Penicillin hypersensitivity
- Possible cross-sensitivity with other beta-lactam antibiotics
- Contraindicated for patients with previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice
Side Effects
- Uncommon and mainly of a mild and transitory nature
- Gastrointestinal side effects may be reduced by taking Co-amoxiclav at the start of meals
- Rare cases of hepatitis, cholestatic jaundice, and allergic skin reactions
Pregnancy & Lactation
- No teratogenic effect observed in animal studies
- Limited data on human pregnancy
- Trace quantities of Amoxicillin detected in breast milk
Precautions & Warnings
- Use with care in patients on anticoagulation therapy or with severe hepatic dysfunction
- Dosage adjustment required for patients with moderate or severe renal impairment
Use in Special Populations
- Dose adjustment required for patients with renal impairment
- Caution and monitoring required for patients with hepatic impairment
Overdose Effects
- Gastrointestinal symptoms and disturbance of fluid and electrolyte balances may be evident
- Co-amoxiclav may be removed from circulation by haemodialysis
Therapeutic Class
- Broad spectrum penicillins
Reconstitution
- IV injection should be reconstituted with Water for Injection BP
- Reconstituted solution may be injected into the drip tubing of infusion fluids
Storage Conditions
- Store below 25°C, protected from light and moisture
- Reconstituted suspension should be kept in the refrigerator (but not frozen) for up to 7 days
- Reconstituted vial must be used within 20 minutes