Rotomycin 300 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Roxithromycin |
| Company | Kemiko pharmaceuticals ltd |
Title
- Rotomycin
Categories
- Antibiotics
- Macrolides
- Medication
Description
Rotomycin is a medication used in the treatment of various infections caused by susceptible microorganisms.
Indications
- Respiratory Infections
- ENT Infections
- Skin Infections
- Genital Infections
Pharmacology
Roxithromycin inhibits protein synthesis by irreversibly binding to the 50s ribosomal subunits, thus blocking the transpeptidation or translocation reactions of susceptible organisms resulting in stunted cell growth.
Dosage and administration
- Adult Dose
- Pediatric Dose
Interaction
- Cytochrome P-450 Binding Sites Affinity
- Theophylline Interaction
- Carbamazepine Interaction
- Warfarin Interaction
Contraindications
- Simultaneous administration with ergotamine or its derivatives
Side effects
- Nausea
- Abdominal Pain
- Diarrhea
- Hypersensitivity Rash
- Vomiting
- Dizziness
- Headache
- Pruritus
- Dyspepsia
- Flatulence
- Tinnitus
- Vertigo
- Constipation
Pregnancy and lactation
The safety of Roxithromycin in pregnancy has not been established. It appears in breast milk in small amounts and does not produce adverse effects in the breastfed infant.
Precautions and warnings
- Hypersensitivity History
- Hepatic Diseases
Therapeutic class
- Macrolides
Antibacterial properties
- Active Against Gram-positive Bacteria
- Active Against Gram-negative Bacteria
- Active Against Atypical Pathogens
Microorganisms
- Staphylococci
- Streptococci
- Listeria
- Corynebacteria
- Gonococci
- Haemophilus Influenzae
- Haemophilus Ducreyi
- Legionella
- Mycoplasma
- Chlamydia
Tolerance
Well tolerated by adults and children
Dosage recommendations
One 300 mg tablet once daily for adults or one 150 mg tablet twice a day
Absorption factors
- Best administered on an empty stomach
- No effect on absorption by antacids or H2-receptor antagonists
Dosage adjustment
150 mg once daily in severe hepatic impairment for adults
Pediatric guidelines
- 2.5 to 5 mg/kg body weight twice a day
- Specific dosages based on body weight
Course of therapy
Normally between 5 and 10 days
Drug interactions
- Mild interaction with theophylline
- No interaction with antacids, H2-receptor antagonists, or food
Side effects percentage
Less than 4% of treated patients complain of side effects
Minor side effects
- Nausea
- Abdominal Pain
- Diarrhoea
- Hypersensitivity Rash
Other minor side effects
- Vomiting
- Dizziness
- Headache
- Pruritus
- Dyspepsia
- Flatulence
- Tinnitus
- Vertigo
- Constipation
Breastfeeding
Roxithromycin appears in breast milk in small amounts and does not produce adverse effects in the breastfed infant
Use in hepatic patients
Dose should not exceed 150 mg twice a day in patients with hepatic diseases