Clindabac 300 mg (Capsule)
Medicine Details
| Category | Details |
|---|---|
| Generic | Clindamycin |
| Company | Popular pharmaceuticals ltd |
| Also available as |
Indications
- Upper respiratory infections
- Lower respiratory infections
- Skin and soft tissue infections
- Bone and joint infections
- Pelvic infections
- Intra-abdominal infections
- Septicemia and endocarditis
- Dental infections
- Multi-drug resistant Plasmodium falciporum infection
Description
Clindabac is a lincosamide antibiotic used in the treatment of infections caused by susceptible microorganisms. Clindabac is a semisynthetic antibiotic derived from lincomycin.
Dosage & Administration
- Clindamycin Capsule:
- 150 mg-300 mg every six hours for serious infections
- 300 mg-450 mg every six hours for more severe infections
- Clindamycin Powder for oral solution:
- 8-12 mg/kg/day divided into 3 or 4 equal doses for serious infections
- 13-16 mg/kg/day divided into 3 or 4 equal doses for severe infections
- 17-25 mg/kg/day divided into 3 or 4 equal doses for more severe infections
- Clindamycin IV/IM Injection:
- 600-1200 mg/day in 2- 4 equal doses for serious infections in adults
- 1200-2700 mg/day in 2-4 equal doses for more severe infections in adults
Interaction
Clindabac enhances the action of other neuromuscular blocking agents and should be used with caution in patients receiving such agents. Antagonism has been demonstrated between Clindabac and erythromycin in vitro.
Contraindications
Clindamycin is contraindicated in patients previously found to be sensitive to clindamycin or any of the ingredients of this medicine.
Side Effects
- Abdominal pain
- Oesophagitis and oesophageal ulcer
- Nausea
- Vomiting
- Diarrhea
- Pruritus
- Skin rashes
- Urticaria
Pregnancy & Lactation
- Pregnancy Category B
- Clindamycin crosses the placenta in humans
- Clindamycin has been reported to appear in breast milk
Precautions & Warnings
Clindabac should be prescribed with caution in individuals with a history of gastrointestinal disease, particularly colitis.
Use in Special Populations
- Use in newborns and infants: Appropriate monitoring of organ system functions is desirable
- Geriatric use: Dose adjustment of Clindabac is not necessary
Overdose Effects
Overdosage with orally administered Clindabac has been rare. Adverse reactions similar to those seen with normal doses can be expected, however, unexpected reactions could occur. Haemodialysis and peritoneal dialysis are not effective in removing Clindabac from the serum.
Therapeutic Class
Macrolides
Reconstitution
- Powder for oral solution: Shake the bottle well to loosen the powder. Add 80 ml of boiled and cooled water to the dry mixture in the bottle. The reconstituted solution should be used within 2 weeks if kept at room temperature.
- Clindabac injection for intravenous use:
- Clindabac phosphate must be diluted prior to IV administration
- Infusion rates should not exceed 30 mg per minute
- Physical and biological compatibility studies have demonstrated no inactivation or incompatibility
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.