Chlorool 125 mg/5 ml (Oral Suspension)
60 ml bottle: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Chloramphenicol oral |
| Company | Seema pharmaceuticals ltd |
| Also available as |
Indications
- Antibiotic for serious infections
- Infections caused by susceptible organisms
- Initiating antibiotic therapy
- Clinical impression based therapy
- In vitro sensitivity tests
- Continuation based on severity
- Efficacy of various drugs
Pharmacology
- Bacteriostatic effect on Gram-negative bacteria
- Bacteriostatic effect on Gram positive bacteria
- Active against rickettsiae
- Active against lymphogranuloma-psittacosis group
- Active against Vibrio cholerae
- Particularly active against Salmonella typhi
- Particularly active against Haemophilus influenzae
- Interference with protein synthesis
- Rapid absorption from GI tract
- Excretion in urine and feces
- Distribution in liver, kidney, and brain
- Penetration into cerebrospinal fluid
Dosage & Administration
- Therapeutic dosage
- Expected inhibition concentrations
- Dosage adjustment for specific circumstances
- Close observation for adverse reactions
- Dosage reduction for adverse reactions
- Dosage adjustment for hepatic or renal impairment
- Effective dosage for adult patients
- Increased dosage for moderately resistant organisms
- Dosage adjustment for pediatric patients
- Dosage adjustment for newborn infants
Interaction
- Retardation of biotransformation of other drugs
- Caution in concomitant administration with specific drugs
- Competitive inhibition with specific antibiotics
- Reduction of concentrations with rifampin therapy
Contraindications
- Hypersensitivity or toxic reaction to the product
- Not for trivial infections
- Not for viral influenza
- Not for infections of the throat
- Not as a prophylactic agent for bacterial infections
Precautions & Warnings
- Close monitoring of hematologic functions
- Early detection of peripheral hematologic changes
- Inability to detect bone marrow depression
- Potential development of aplastic anemia
Overdose Effects
- Toxicity levels exceeding 25 mcg/ml
- Hematologic effects
- Increasing serum iron levels
- Nausea, vomiting, and diarrhea
- Charcoal hemoperfusion for removing Chlorool
- Questionable value of exchange transfusion
Therapeutic Class
- Macrolides
Storage Conditions
- Cool and dry place
- Securely closed bottle
- Protection from light