A-Phenicol 0.5% (Ophthalmic Solution)

Indications

• Treatment of ocular infections
• Infections of conjunctiva and cornea
• Susceptible organisms include Staphylococcus aureus, Streptococcus pneumoniae, E.coli, etc.

Pharmacology

• Broad-spectrum bacteriostatic antibiotic
• Inhibits bacterial protein synthesis
• Interferes with transfer of activated amino acids

Dosage & Administration

• 1 or 2 drops in the conjunctival sac
• 4-6 times per day for the first 72 hours
• Every 4 hours thereafter
• Treatment duration approximately 7 days
• Avoid use for more than 3 weeks without re-evaluation

Interaction

• Inhibits Chymotrypsin

Contraindications

• Hypersensitivity to Chloramphenicol or any ingredients

Side Effects

• Burning
• Stinging
• Conjunctival hyperemia
• Blood dyscrasia
• Allergic or inflammatory reactions
• Vesicular and maculopapular dermatitis

Pregnancy & Lactation

• Safety not established for use in pregnancy and lactation
• Use only when considered essential by physicians

Precautions & Warnings

• Avoid for minor infections or prophylaxis
• Avoid repeated or prolonged treatment
• Risk of blood dyscrasias

Overdose Effects

• Unlikely to cause toxicity due to low antibiotic content

Therapeutic Class

• Ear Anti-Infectives & Antiseptics
• Eye Anti-Infectives & Antiseptics
• Macrolides

Storage Conditions

• Store between 2°C-8°C
• Protect from light
• Keep out of reach of children
• Do not touch dropper tip to surface
• Do not use after 30 days of first opening

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