Clamox (1 gm+200 mg)/20 ml (IV Injection)

1.2 gm vial: ৳ 300.00

Medicine Details

Category Details
Generic Amoxicillin clavulanic acid
Company Opsonin pharma ltd
Also available as
Clamox 500 mg injection Clamox 125 mg suspension Clamox 875 mg tablet Clamox 250 mg tablet Clamox 500 mg tablet Clamox ds 400 mg suspension

Indications

  • Upper respiratory tract infections (tonsillitis, sinusitis, otitis media)
  • Lower respiratory tract infections (acute and chronic bronchitis, pneumonia)
  • Genito-urinary tract infections (cystitis, urethritis, pyelonephritis)
  • Skin and soft tissue infections
  • Bone and joint infections
  • Other infections (septic abortion, puerperal sepsis)

Composition

  • 375 mg tablet: Amoxicillin 250 mg + Clavulanic Acid 125 mg
  • 625 mg tablet: Amoxicillin 500 mg + Clavulanic Acid 125 mg
  • 1 gm tablet: Amoxicillin 875 mg + Clavulanic Acid 125 mg
  • Powder for Suspension: Amoxicillin 125 mg + Clavulanic Acid 31.25 mg
  • Powder for Suspension (Forte): Amoxicillin 400 mg + Clavulanic Acid 57.5 mg
  • 1.2 gm Injection: Amoxicillin Sodium 1 gm + Clavulanate Potassium 200 mg
  • 0.6 gm Injection: Amoxicillin Sodium 500 mg + Clavulanate Potassium 100 mg

Pharmacology

  • Pharmacodynamic properties: Broad spectrum bactericidal activity against many Gram-positive & Gram-negative microorganisms
  • Pharmacokinetic properties: Peak serum levels of both components occur about one hour after oral administration

Dosage

  • Adult: 625 mg Tablet every 12 hours or 375 mg Tablet every 8 hours for usual dose
  • Children: Dosage based on age and weight

Administration

  • Oral dosage form can be taken without regard to meals
  • IV injection suitable for intravenous administration
  • Reconstituted vial must be used within 20 minutes

Interaction

  • Potential reduction in efficacy of oral contraceptives
  • Concomitant use of allopurinol can increase likelihood of allergic skin reactions

Contraindications

  • History of penicillin hypersensitivity
  • Cross-sensitivity with other beta-lactam antibiotics
  • Patients with previous Co-amoxiclav or penicillin-associated cholestatic jaundice

Side Effects

  • Uncommon and mainly mild and transient
  • Gastrointestinal side effects can be reduced by taking with meals
  • Rare reports of hepatitis, cholestatic jaundice, skin reactions, angioedema, and anaphylaxis

Pregnancy & Lactation

  • Not recommended unless considered essential by physician
  • Trace quantities can be detected in breast milk

Precautions & Warnings

  • Use with care in patients on anticoagulation therapy or severe hepatic dysfunction
  • Dosage adjustment in patients with moderate or severe renal impairment

Use in Special Populations

  • Adjust dosage in renal impairment
  • Monitor hepatic function at regular intervals

Overdose Effects

  • Gastrointestinal symptoms, disturbance of fluid and electrolyte balances
  • May be removed from circulation by haemodialysis

Therapeutic Class

Broad spectrum penicillins

Reconstitution

IV injection can be reconstituted with Water for Injection BP

Storage Conditions

  • Store below 25°C, protected from light and moisture
  • Reconstituted suspension to be kept in refrigerator and used within 7 days
  • Reconstituted vial must be used within 20 minutes

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