Linzolid 100 mg/5 ml (Powder for Suspension)
100 ml bottle: ৳ 280.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Linezolid |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Product Title
Linzolid Medicine
Categories
- Antibiotic
- Medication
- Pharmaceutical
Description
Linzolid is indicated for the treatment of nosocomial pneumonia, community-acquired pneumonia, complicated skin and skin structure infection, uncomplicated skin and skin structure infections, and Vancomycin-resistant Enterococcus faecium infections. It is a synthetic, antibacterial agent belonging to oxazolidinones with in vitro activity against Gram-positive and certain Gram-negative bacteria. Linezolid tablets should be taken in oral route with or without food. Linezolid IV infusion should be administered by intravenous infusion over a period of 30 to 120 minutes.
Dosage and Administration
- Infections:
- Nosocomial pneumonia
- Community-acquired pneumonia
- Complicated skin and skin structure infections
- Uncomplicated skin and skin structure infections
- Vancomycin-resistant Enterococcus faecium infections
- Recommended Dosage:
- Pediatric Patients: 10 mg/kg orally or intravenously every 8 hours
- Adults and Adolescent: 600 mg orally or intravenously every 12 hours
- Recommended Duration of Treatment: 10 to 28 consecutive days
- Intravenous Administration: Administered by intravenous infusion over a period of 30 to 120 minutes
- Hepatic Impairment: No dose adjustment is recommended for patients with mild-to-moderate hepatic impairment
- Use in Children and Adolescents: The dose of linezolid for children and adolescents have been described
Interaction
- Drug Interaction with Medication: Linzolid is a reversible, nonselective inhibitor of monoamine oxidase
- Interaction with Food and Others: Advice patients to avoid large quantities of foods or beverages with high tyramine content while taking Linzolid
Contraindications
- Known hypersensitivity to Linezolid or any of the other product components
- Patients taking any medicinal product which inhibits monoamine oxidases A or B
- Uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, carcinoid syndrome
- Patients taking directly and indirectly acting sympathomimetic agents, vasopressive agents, dopaminergic agents, serotonin re-uptake inhibitors, tricyclic antidepressants, serotonin 5-HT1 receptor agonists, meperidine or buspirone
Side Effects
- Most Common Adverse Events:
- Diarrhea
- Headache
- Nausea
- Other Adverse Events:
- Oral moniliasis
- Vaginal moniliasis
- Hypertension
- Dyspepsia
- Localized abdominal pain
- Pruritus
- Tongue discoloration
Pregnancy and Lactation
- Pregnancy: Available data with linezolid use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes
- Lactation: Linezolid is present in breast milk. Advise lactating women to monitor a breastfed infant for diarrhea and vomiting
Precautions and Warnings
- Complete blood counts should be monitored weekly in patients who receive Linzolid
- Prompt ophthalmic evaluation is recommended if patients experience symptoms of visual impairment
- Cautious use in patients with catheter-related bloodstream infections or catheter-site infections
- Careful monitoring for potential increases in blood pressure
- Immediate medical evaluation for patients with recurrent nausea or vomiting, unexplained acidosis or low bicarbonate level
- Dose adjustment may be required if hypoglycemia occurs
Overdose Effects
No cases of overdose have been reported. Symptomatic and supportive care is advised together with maintenance of glomerular filtration