Hepaximin 550 mg (Tablet)

Unit Price: ৳ 55.00 (1 x 10: ৳ 550.00)
Strip Price: ৳ 550.00

Medicine Details

Category Details
Generic Rifaximin
Company Aristopharma ltd
Also available as
Hepaximin 200 mg tablet

Indications

  • Traveler's diarrhea treatment
  • Reduction in risk of overt hepatic encephalopathy
  • Bacterial overgrowth of irritable bowel syndrome

Pharmacology

  • Semisynthetic
  • Rifamycin-based non-systemic antibiotic
  • Inhibits bacterial RNA synthesis
  • Bactericidal action against many species of Gram-positive and Gram-negative bacteria

Dosage & Administration

  • Traveler's Diarrhea: 200 mg 3 times daily for 3 days (≥12 years of age)
  • Hepatic Encephalopathy: 550 mg 2 times daily (≥18 years of age)
  • Bacterial overgrowth of irritable bowel syndrome: 400 mg 3 times daily for 10 days or 550 mg 3 times daily for 14 days (≥18 years of age)

Interaction

  • Induces CYP3A4 (in vitro study)
  • Not expected to induce CYP3A4 in patients with normal liver function

Contraindications

  • Hypersensitivity to Rifaximin or to any rifamycin antimicrobial agents

Side Effects

  • Flatulence
  • Headache
  • Abdominal pain
  • Rectal tenesmus
  • Defecation urgency
  • Nausea
  • Constipation
  • Pyrexia
  • Vomiting
  • Anaphylaxis
  • Angioneurotic edema
  • Exfoliative dermatitis

Pregnancy & Lactation

  • Pregnancy category C
  • Unknown excretion in human milk

Precautions & Warnings

  • Not effective in patients with diarrhea complicated by fever and/or blood in the stools
  • Discontinue if diarrhea symptoms worsen or persist for more than 24-48 hours
  • Consider alternative antibiotic therapy
  • Pseudomembranous colitis risk
  • Consider in patients presenting with diarrhea after antibacterial agent administration

Use in Special Populations

  • Renal Impairment: Pharmacokinetics not studied in patients with impaired renal function
  • Hepatic Impairment: Markedly elevated systemic exposure in hepatic impairment patients

Overdose Effects

  • No specific information available
  • Discontinue Hepaximin
  • Treat symptomatically
  • Supportive measures as required

Therapeutic Class

  • 4-Quinolone preparations

Storage Conditions

  • Keep below 30°C
  • Away from light & moisture
  • Keep out of the reach of children

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