Rifacol 550 mg (Tablet)
Unit Price: ৳ 45.13 (1 x 10: ৳ 451.31)
Strip Price: ৳ 451.31
Medicine Details
| Category | Details |
|---|---|
| Generic | Rifaximin |
| Company | Sharif pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of traveler's diarrhea by noninvasive strains of E. coli
- Reduction in risk of overt hepatic encephalopathy
- Bacterial overgrowth of irritable bowel syndrome.
Pharmacology
- Semisynthetic, rifamycin-based non-systemic antibiotic
- Inhibits bacterial RNA synthesis by its action on the beta-subunit of the DNA-dependent RNA polymerase
- Broad spectrum activity against Gram-positive and Gram-negative, aerobic and anaerobic bacteria
Dosage & Administration
- For patients ≥12 years of age: 200 mg 3 times daily for 3 days for traveler's diarrhea
- For patients ≥18 years of age: 550 mg 2 times daily for hepatic encephalopathy
- 400 mg 3 times daily for 10 days or 550 mg 3 times daily for 14 days for bacterial overgrowth of irritable bowel syndrome
Interaction
In vitro study has suggested that Rifacol induces CYP3A4, but at the recommended dosing regimen is not expected to induce CYP3A4
Contraindications
Hypersensitivity to Rifaximin, rifamycin antimicrobial agents, or any components of this product
Side Effects
- Flatulence
- Headache
- Abdominal pain
- Rectal tenesmus
- Defecation urgency
- Nausea
- Constipation
- Pyrexia
- Vomiting
- Reactions like anaphylaxis, angioneurotic edema, and exfoliative dermatitis
Pregnancy & Lactation
Pregnancy category C, not known whether Rifaximin is excreted in human milk
Precautions & Warnings
- Not found to be effective in patients with diarrhea complicated by fever and/or blood in the stools
- Rifacol therapy should be discontinued if diarrhea symptoms worsen or persist for more than 24-48 hours
- Consider pseudomembranous colitis in patients with diarrhea after antibacterial therapy
Use in Special Populations
- Pharmacokinetics in patients with impaired renal function has not been studied
- Systemic exposure elevated in hepatic impairment
Overdose Effects
No specific information available on the treatment of overdose with Rifacol
Therapeutic Class
4-Quinolone preparations
Storage Conditions
Keep below 30°C temperature, away from light & moisture, out of the reach of children