Henlix 550 mg (Tablet)
Unit Price: ৳ 45.00 (2 x 5: ৳ 450.00)
Strip Price: ৳ 225.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rifaximin |
| Company | Aci limited |
| Also available as |
Indications
- Treatment of traveler's diarrhea by noninvasive strains of E. coli
- Reduction in risk of overt hepatic encephalopathy
- Bacterial overgrowth of irritable bowel syndrome
Pharmacology
Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic that inhibits bacterial RNA synthesis by its action on the beta-subunit of the DNA-dependent RNA polymerase.
Dosage & Administration
- Traveler's Diarrhea: For patients ≥12 years of age: 200 mg 3 times daily for 3 days
- Hepatic Encephalopathy: For patients ≥18 years of age: 550 mg 2 times daily
- Bacterial overgrowth of irritable bowel syndrome:
- 400 mg 3 times daily for 10 days
- 550 mg 3 times daily for 14 days
- Can be taken with or without food: 1
Interaction
In vitro study has suggested that Henlix induces CYP3A4. However, in patients with normal liver function, Henlix at the recommended dosing regimen is not expected to induce CYP3A4.
Contraindications
- Hypersensitivity to Rifaximin or to any of the rifamycin antimicrobial agents
- Hypersensitivity to any components of this product
Side Effects
- Flatulence
- Headache
- Abdominal pain
- Rectal tenesmus
- Defecation urgency
- Nausea
- Constipation
- Pyrexia
- Vomiting
- Anaphylaxis
- Angioneurotic edema
- Exfoliative dermatitis
Pregnancy & Lactation
- Pregnancy category: C
- Excretion in human milk: Not known
Precautions & Warnings
- Not effective in patients with diarrhea complicated by fever and/or blood in the stools
- Discontinue therapy if diarrhea symptoms worsen or persist for more than 24-48 hours
- Consider alternative antibiotic therapy if needed
- Pseudomembranous colitis has been reported with nearly all antibacterial agents
Use in Special Populations
- Renal Impairment: The pharmacokinetics of Henlix in patients with impaired renal function has not been studied
- Hepatic Impairment: Systemic exposure of Henlix was markedly elevated in patients with hepatic impairment compared to healthy subjects
Overdose Effects
No specific information is available on the treatment of overdose with Henlix. Discontinue Henlix, treat symptomatically, and institute supportive measures as required.
Therapeutic Class
4-Quinolone preparations
Storage Conditions
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.