Rifamax 550 mg (Tablet)
Unit Price: ৳ 45.00 (1 x 10: ৳ 450.00)
Strip Price: ৳ 450.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rifaximin |
| Company | Incepta pharmaceuticals ltd |
| Also available as |
Title
- Rifamax
Categories
- Medicine
- Therapeutic
Description
- Rifamax is a medication indicated for the treatment of traveler's diarrhea by noninvasive strains of E. coli, reduction in risk of overt hepatic encephalopathy, and bacterial overgrowth of irritable bowel syndrome. It is a non-systemic antibiotic that inhibits bacterial RNA synthesis with broad spectrum activity against many species of bacteria. The dosage varies based on the condition being treated and the patient's age. Rifamax is contraindicated in patients with hypersensitivity to Rifaximin or to any of the rifamycin antimicrobial agents.
Indications
- Treatment of traveler's diarrhea by noninvasive strains of E. coli
- Reduction in risk of overt hepatic encephalopathy
- Bacterial overgrowth of irritable bowel syndrome
Pharmacology
- Rifaximin is a semisynthetic, rifamycin-based non-systemic antibiotic. It inhibits bacterial RNA synthesis by its action on the beta-subunit of the DNA-dependent RNA polymerase. It shows broad spectrum activity against many species of Gram-positive and Gram-negative, aerobic and anaerobic bacteria.
Dosage & Administration
- For traveler's diarrhea: 200 mg 3 times daily for 3 days (patients ≥12 years of age)
- For hepatic encephalopathy: 550 mg 2 times daily (patients ≥18 years of age)
- For bacterial overgrowth of irritable bowel syndrome: 400 mg 3 times daily for 10 days or 550 mg 3 times daily for 14 days; can be taken with or without food
Interaction
- In vitro study has suggested that Rifamax induces CYP3A4. However, in patients with normal liver function, Rifamax at the recommended dosing regimen is not expected to induce CYP3A4.
Contraindications
- Hypersensitivity to Rifaximin or to any of the rifamycin antimicrobial agents, or any components of this product
Side Effects
- Flatulence
- Headache
- Abdominal pain
- Rectal tenesmus
- Defecation urgency
- Nausea
- Constipation
- Pyrexia
- Vomiting
- Anaphylaxis
- Angioneurotic edema
- Exfoliative dermatitis
Pregnancy & Lactation
- Pregnancy category C
- Unknown excretion in human milk
Precautions & Warnings
- Not effective in patients with diarrhea complicated by fever and/or blood in the stools
- Discontinue Rifamax if diarrhea symptoms worsen or persist for more than 24-48 hours
- Consider alternative antibiotic therapy if needed
- Be cautious of pseudomembranous colitis
Use in Special Populations
- Renal Impairment: Pharmacokinetics not studied in patients with impaired renal function
- Hepatic Impairment: Markedly elevated systemic exposure in patients with hepatic impairment compared to healthy subjects
Overdose Effects
- No specific information available on the treatment of overdose with Rifamax
- Discontinue Rifamax, treat symptomatically, and institute supportive measures as required
Therapeutic Class
- 4-Quinolone preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light & moisture
- Keep out of the reach of children