Covan 1 gm/vial (IV Infusion)

1 gm vial: ৳ 480.00

Medicine Details

Category Details
Generic Vancomycin hydrochloride
Company Renata limited
Also available as
Covan 500 mg injection

Title and Category

  • Covan Antimicrobial Drug
  • Medicine
  • Antibiotic

Indications

  • Treatment of potentially life-threatening infections
  • Useful in severe staphylococcal infections
  • Therapy for endocarditis
  • Prophylaxis against endocarditis
  • Effective in osteomyelitis, pneumonia, septicemia, and soft tissue infections

Mode of Action

  • Binds tightly to D-alanyl-D-alanine portion of cell wall precursor
  • Blocks glycopeptide polymerisation
  • Inhibits cell wall synthesis
  • Causes damage to the cytoplasmic membrane

Dosage and Administration

  • Concentration recommendation for adults
  • Dosage for patients with normal renal function
  • Dosage for patients with impaired renal function and elderly patients
  • Dosage for antibiotic-associated pseudomembranous colitis
  • Dosage for staphylococcal enterocolitis
  • Dosage for pediatrics

Contraindications

  • Not to be used in patients with known hypersensitivity to Vancomycin

Side Effects

  • Well tolerated
  • Possible rapid infusion-related anaphylactic reactions
  • Potential flushing of upper body
  • Injection site pain and thrombophlebitis
  • Possible tissue irritation and injection site necrosis
  • Potential overgrowth of non-susceptible organisms

Pregnancy and Lactation

  • Caution in pregnancy, monitor blood levels to minimize risk of foetal toxicity
  • Exercise caution when administered to nursing women

Precautions and Warnings

  • Serial tests of auditory function and blood levels for patients with borderline renal function and individuals over the age of 60
  • Periodic haematological studies, urine analysis, and renal function tests for all patients
  • Intravenous infusion only, as injection site necrosis occurs when injected intramuscularly
  • Careful observation for superinfection and pseudomembranous colitis due to C. difficile

Overdose Effects

  • Supportive care advised
  • Maintenance of glomerular filtration
  • Poor removal from blood by haemodialysis or peritoneal dialysis
  • Limited benefit reported with haemoperfusion using Amberlite resin XAD-4

Therapeutic Class

  • Other antibiotic

Storage Conditions

  • Store in a cool and dry place
  • Protect from light
  • Keep out of reach of children

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